Every viral replication is an event that could yield a new variant. A new variant can lead to new problems. It is therefore of interest to limit viral replicati

Every viral replication is an event that could yield a new variant. A new variant can lead to new problems. It is therefore of interest to limit viral replications. This, in addition to the health care system capacities, are crucial targets to address. Fortunately, vaccines can improve both targets due to the reduced (though now less effectively so) infection rates, shorter infection periods, etc. This makes me personally hopeful that Omicron will become the final "pre-endemic" variant. However, while I too feel tired and sympathize with the described "vaxxed and done" mentality, I know we must stay vigilant and continue to reduce opportunities for this virus to find new ways to remain a pan- rather than an endemic. Acceptable costs of this vigilance, and the nature of it, i.e. the measures we take, need to be updated just as everything else.