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For all vaccines, neutralizing antibody titers decrease over time. This is why boosters exist in the first place.

denimnerd42 5y ago
From what I've seen so far the antibodies don't really last long enough. I'll rely on long term t-cell protection. At least that's what I think so far.
jaywalk 5y ago
No vaccine has ever had an efficacy dropoff as steep and rapid as the current crop of Covid vaccines.
- stefan_ 5y ago
  "The current crop of Covid vaccines" all of which are engineered based on the original variant. Ignorance like this has contributed to the virus mutating, and obviously the newer variants have increased fitness against whatever immune response the original one provokes - otherwise it wouldn't exist.
  - djrogers 5y ago
    If you look at the history of vaccinations against other diseases like measles, mumps, rubella, polio, smallpox, etc. you won't see untying like what we're seeing now - those were all able to be largely or completely eradicated. What we appear to have with COVID-19 is akin to influenza - endemic, will never be eradicated, and thus it will mutate regularly and require new vaccines/boosters. Given that, people understandably want to treat it like the flu and get back to normal life. > Ignorance like this has contributed to the virus mutating Ignorance contributes nothing to the virus - it doesn't care if you have knowledge or not. This virus was going to mutate faster than we could produce vaccine no matter what we did.
- Ichthypresbyter 5y ago
  No vaccine has ever had its efficacy measured in terms of infection detectable by PCR test.
Mikeb85 5y ago
It's always been understood that antibodies wane over time. That's why other cells in our bodies 'remember' viral infections and essentially are primed to create antibodies again when infected (https://www.nature.com/articles/s41586-020-2550-z https://www.nature.com/articles/s41586-020-2550-z)

From what I've seen so far the antibodies don't really last long enough. I'll rely on long term t-cell protection. At least that's what I think so far.

jaywalk 5y ago

No vaccine has ever had an efficacy dropoff as steep and rapid as the current crop of Covid vaccines.

stefan_ 5y ago
"The current crop of Covid vaccines" all of which are engineered based on the original variant. Ignorance like this has contributed to the virus mutating, and obviously the newer variants have increased fitness against whatever immune response the original one provokes - otherwise it wouldn't exist.
- djrogers 5y ago
  If you look at the history of vaccinations against other diseases like measles, mumps, rubella, polio, smallpox, etc. you won't see untying like what we're seeing now - those were all able to be largely or completely eradicated. What we appear to have with COVID-19 is akin to influenza - endemic, will never be eradicated, and thus it will mutate regularly and require new vaccines/boosters. Given that, people understandably want to treat it like the flu and get back to normal life. > Ignorance like this has contributed to the virus mutating Ignorance contributes nothing to the virus - it doesn't care if you have knowledge or not. This virus was going to mutate faster than we could produce vaccine no matter what we did.
Ichthypresbyter 5y ago
No vaccine has ever had its efficacy measured in terms of infection detectable by PCR test.

Mikeb85 5y ago

It's always been understood that antibodies wane over time. That's why other cells in our bodies 'remember' viral infections and essentially are primed to create antibodies again when infected (https://www.nature.com/articles/s41586-020-2550-z https://www.nature.com/articles/s41586-020-2550-z)