4 ms·
This is a pretty non-controversial paper and doesn't contain anything shocking or previously unknown, but the title has the potential to cause controversy. Here
by ageitgey 5y ago
This is a pretty non-controversial paper and doesn't contain anything shocking or previously unknown, but the title has the potential to cause controversy. Here's my quick summary:
- Previous vaccines for HPV, Hepatitis B and Flu are known to (rarely) trigger or worsen autoimmune diseases such as Guillain-Barré syndrome.
- Lots of new Covid vaccines have been created globally using a wide variety of technologies (mRNA, Adenovirus vector, inactivated virus, etc), so it stands to reason they could trigger rare side effects and different technologies might be associated with different side-effects.
- It seems wise to research how different side-effects might happen with each type of vaccine.
- These side-effects are so rare that it has not been proven they are caused by the vaccines - "However, whether the association between COVID-19 vaccine and autoimmune manifestations is coincidental or causal remains to be elucidated." But given the timing of them occurring in large populations post-vaccination, it's worth researching the possible mechanisms to figure out why they happen and see if they can be prevented.
- Even when side effects do occur, they can typically be treated using the standard protocols for each condition. But the more we know about them, the better we would be at treating them and at predicting which patients would be more likely to be at risk of developing them.
- The risk of rare side effects does not mean that populations shouldn't be vaccinated, because the risks of COVID-19 itself are higher - "We encourage and support COVID-19 vaccination globally to create an immunity barrier among population."
- But we should monitor for side-effects and learn about the mechanisms at work so we can prevent them, possibly by screening patients most at risk - "Systematic monitoring and ongoing follow-up of autoimmune events will be critical in identifying potential associations between autoimmune manifestations and COVID-19 vaccination, specific mechanisms of diagnosis and risk stratification for future vaccination."
So in short, let's all be grown ups and study the rare side-effects of vaccines so we can make them every more rare through better prevention and/or treatment.
Here are the specific conditions they theorize might be (in rare cases) triggered or worsened by the two most common types of vaccines in the West:
mRNA (Pfizer, Moderna)
- Vaccine-induced immune thrombotic thrombocytopenia (i.e your blood won't clot well)
- Immune thrombocytopenic purpura (bruising caused by low platelets)
- Autoimmune liver diseases
- Guillain–Barré syndrome
- IgA nephropathy (i.e. kidney problems)
- Rheumatoid arthritis
- Graves' disease (i.e. thyroid problems)
- Type 1 diabetes mellitus
Adenovirus vector (Johnson & Johnson, AstraZenica)
- Vaccine-induced immune thrombotic thrombocytopenia (i.e your blood won't clot well)
- Autoimmune liver diseases
- Guillain–Barré syndrome
- Rheumatoid arthritis
- Systemic lupus erythematosus (i.e. Lupus)
The paper also summarizes how these might be caused, but that's way beyond a summary. Just read the paper of you are interested.
- dwd 5y agoI have an in-law who's been diagnosed with Crohn's disease, having been sick since her second AZ shot.
- robbiep 5y agoNice summary - with apologies I’ll nitpick - I am not aware of VITTP from mRNA vaccines. (Edit - I dial this back - I see the piece in the paper where they mention the case series from mRNA vaccines) I think (I guess the audience of a scientific paper is more general a scientific audience) that it would be nice if there was at least a comparator paragraph to the risks of actual COVID disease. Molecular mimicry is to me the most likely mechanism of the whole thing, and we keep finding out new ways COVID is damaging people down the track - this recent paper (below) shows a reasonably scary rise in both type 1 and type 2 diabetes in those less than 18 with a recent COVID infection. Terrifying. - (source) https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm?s_cid=mm7102e2_w https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm?s_cid=mm...
- walterbell 5y ago> rise in both type 1 and type 2 diabetes in those less than 18 with a recent COVID infection https://twitter.com/j_g_allen/status/1479876564930248708 https://twitter.com/j_g_allen/status/1479876564930248708 > Careful with this study on diabetes. Worth skipping ahead to the limitations section… 1. Single ICD code 2. Differential exposure misclassification 3. No covariates (obesity?!) 4. only included those seeking care + insured > (actually a great teaching case for EPI 101!)
- robbiep 5y agoThank you
- yunohn 5y ago> Even when side effects do occur, they can typically be treated using the standard protocols for each condition. But most of these conditions don’t have great standard treatments? For example, auto-immune conditions are “treated” by taking immunosuppressive medications indefinitely.