3 ms·

is anyone able to explain this in plain english please ?

dtech 5y ago
I'm not an immunologist, but skimming through this it seems to describe patient cases who developed auto-immune disorders after - not necessarily because of - a mRNA covide vaccine, and describes possible causal chains in the immune system. Since these cases emerged within a month, it seems to describe extremely rare side-effects rather than anything widespread but as of now yet unknown.
- rsfern 5y ago
  One thing to note - they cover case reports following six major vaccine platforms, not just the mRNA ones. The review seems pretty good about differentiating when summarizing, but a lot (maybe a third?) of their descriptions of the individual case reports don’t specify which vaccine was given so you have to jump to the cited report in those cases.
ggm 5y ago
It's a catalogue of potential side effects. What they don't state is frequency, and variance from normal population. Nor do they discuss viral risks of the same diseases. Basically it's saying "this can happen" and that's useful but it would have helped enormously if they had said how many instances in what size cohorts.
- creshal 5y ago
  The individual studies they're referencing do that. Overall, there's a risk, but it's negligible with sufficient monitoring.
creshal 5y ago
This meta-study summarises various studies that look into reported cases of auto-immune problems after vaccination. Most of these are in the order of 1-2 cases per million vaccine doses, and often close to the natural background rate of these problems manifesting in otherwise healthy individuals: If you look at 100,000 people for a year, you expect 2 of them to contract Guillain–Barré syndrome naturally, 1 to develop blood clots, etc. pp. So the various studies also determine if there even is a statistically significant increase or not, which there sometimes is, sometimes isn't. The meta-study summarises all that. And even taken together, all the various problems are not significant enough to counterindicate any of the vaccines, given just how much more dangerous covid infections are: > Although allergic reactions to vaccines are rare, as vaccination programmes are being rolled out globally, many vaccine-related side-effects are being reported. Importantly, we do not aim to disavow the overwhelming benefits of mass vaccination with COVID-19 in controlling COVID-19 pandemic and preventing COVID-19 morbidity and mortality. We encourage and support COVID-19 vaccination globally to create an immunity barrier among population.

I'm not an immunologist, but skimming through this it seems to describe patient cases who developed auto-immune disorders after - not necessarily because of - a mRNA covide vaccine, and describes possible causal chains in the immune system. Since these cases emerged within a month, it seems to describe extremely rare side-effects rather than anything widespread but as of now yet unknown.

rsfern 5y ago
One thing to note - they cover case reports following six major vaccine platforms, not just the mRNA ones. The review seems pretty good about differentiating when summarizing, but a lot (maybe a third?) of their descriptions of the individual case reports don’t specify which vaccine was given so you have to jump to the cited report in those cases.

ggm 5y ago

It's a catalogue of potential side effects. What they don't state is frequency, and variance from normal population. Nor do they discuss viral risks of the same diseases. Basically it's saying "this can happen" and that's useful but it would have helped enormously if they had said how many instances in what size cohorts.

creshal 5y ago
The individual studies they're referencing do that. Overall, there's a risk, but it's negligible with sufficient monitoring.

creshal 5y ago

This meta-study summarises various studies that look into reported cases of auto-immune problems after vaccination. Most of these are in the order of 1-2 cases per million vaccine doses, and often close to the natural background rate of these problems manifesting in otherwise healthy individuals: If you look at 100,000 people for a year, you expect 2 of them to contract Guillain–Barré syndrome naturally, 1 to develop blood clots, etc. pp. So the various studies also determine if there even is a statistically significant increase or not, which there sometimes is, sometimes isn't. The meta-study summarises all that. And even taken together, all the various problems are not significant enough to counterindicate any of the vaccines, given just how much more dangerous covid infections are: > Although allergic reactions to vaccines are rare, as vaccination programmes are being rolled out globally, many vaccine-related side-effects are being reported. Importantly, we do not aim to disavow the overwhelming benefits of mass vaccination with COVID-19 in controlling COVID-19 pandemic and preventing COVID-19 morbidity and mortality. We encourage and support COVID-19 vaccination globally to create an immunity barrier among population.