5 ms·

As does Histamine.

SV_BubbleTime 5y ago
And yeast (via gut bacteria). I’m pretty sure we have been cultivated to breed more of them, not our decision just because they’re delicious.
- BurningFrog 5y ago
  If we've "been cultivated", they're delicious because our (non) ancestors who didn't like the taste got weeded out by evolution.
- Terry_Roll 5y ago
  Bacteria that's crossed the blood brain barrier can affect behaviour. In European woman, the most common bacteria in a woman's vagina's is Lactobacillus largely due to the milk product consumption in their die. However whilst Western medicine considers Lactobacillus to be a probiotic, other cultures who do not consume milk products in as large a quantity have different bacterial profiles in their vagina's. Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. The presence of a particular strain of bacteria (whose name I dont have to hand right now) in a woman's vagina will also predict whether they have freckles or not. Biology is a fascinating subject and very much open to debate.
  - astrange 5y ago
    > Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. Humans are very good at detecting rancid milk from the smell; I believe nobody's developed a machine better than us yet.
  - JohnBooty 5y ago
    Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. Not just Japanese who claim this; I've heard this from non-Japanese Asians as well. I think I remember hearing that there were some specific derogatory terms for Westerners based on this smell, but I could be wrong.
metadat 5y ago
Are you able to elaborate on this? I take a lot of anti-histamines and haven't noticed any difference other than it helps me medically. But I'd like to be on the lookout so I can be my best self.
- antics9 5y ago
  I second this. I take antihistamines from April to September. Loratadin absolutely has a negative effect on my mood. Mostly because I feel tired I believe. Switched to Ebastin and no more tiredness. However, I am starting to suspect that it also does affect my mood in some way or another. During winter I take a pill as a precautionary if I’m going to be in any dusty spaces. The day after I sometimes experience mood swings that I cannot explain.
  - whatshisface 5y ago
    I have found that n95 masks work wonderfully for working in dusty spaces. A dividend of the pandemic I suppose.
    - selectodude 5y ago
      They sell 3M N95 masks at Home Depot for a reason :)
  - throwaway2331 5y ago
    Have you tried mast-cell stabilizers? Ketotifen is one (albeit, still an antihistamine).
  - heavyset_go 5y ago
    Levocetirizine doesn't cross the blood-brain barrier like other antihistamines such as loratadine does.
- Terry_Roll 5y ago
  It increases IQ, histidine, a precursor for histamine, doubled the IQ of people with downs syndrome in an experiment over several months, but histamine also increases aggression which probably explains why you dont see many aggressive people with Down Syndrome. Aged food & drink is higher in histamine. Red wine more than white wine. Dark spirits more than clear spirits. Red meat more than white meat. It can cause spontaneous erections, 60mg of histamine can be used for erectile dysfunction. Histamine can increase blood saturation levels and help reduce the symptoms of COPD and other respiratory problems. If you consumed alot of histadine, like several heaped table spoons with meals throughout the day, depending on your age and health you will notice some or all of the above. Its one of the fastest amino acids into muscle, its untouched by the liver. I dont know why you are taking anti-histamines, histamine helps the white immune cells move through tissue, it causes inflammation, there is also a histamine feedback loop in the brain which affects sleep patterns, which is why anti-histamines can help people get to sleep, but lots of histamine can improve sleep conversely. Loads of studies exist that can be found on Google Scholar, but multiple chemicals affect peoples personality, and their health. If you want to read up on this, also look at the pathways and other chemicals which work with histidine (or any other amino acid) for that matter.
cplusplusfellow 5y ago
Can you expound upon this? As someone with severe allergies I tend to take quite a bit of antihistamines.
- nick__m 5y ago
  An old antihistamine¹ was used as the blueprint for development of the first commercialized SSRI. Similar first generation antihistamines² also have a significant effect on SERT (serotonin transporter). Reciprocly, the weight gain induced by certain SSRI is tought to be caused by an antihistaminic effect³. It would not be surprising if other antihistamines (at least those that cross the BBB) had similar effects because antihistamines are frequently promiscuous (i.e. they have significant affinities with a lots of targets other than the one that make a drug effective) but I would be surprised if histamine, or its inhibition, was directly (with the exclusion of the miserable feeling that comes with allergies) implicated in moods changes. 1- https://en.wikipedia.org/wiki/Brompheniramine https://en.wikipedia.org/wiki/Brompheniramine 2- https://en.wikipedia.org/wiki/Chlorphenamine https://en.wikipedia.org/wiki/Chlorphenamine 3- https://pubmed.ncbi.nlm.nih.gov/27593622 https://pubmed.ncbi.nlm.nih.gov/27593622
captainoats 5y ago
Mirtazapine is a great example of this and can have profound effects on behavior

As does Histamine.

And yeast (via gut bacteria). I’m pretty sure we have been cultivated to breed more of them, not our decision just because they’re delicious.

BurningFrog 5y ago
If we've "been cultivated", they're delicious because our (non) ancestors who didn't like the taste got weeded out by evolution.
Terry_Roll 5y ago
Bacteria that's crossed the blood brain barrier can affect behaviour. In European woman, the most common bacteria in a woman's vagina's is Lactobacillus largely due to the milk product consumption in their die. However whilst Western medicine considers Lactobacillus to be a probiotic, other cultures who do not consume milk products in as large a quantity have different bacterial profiles in their vagina's. Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. The presence of a particular strain of bacteria (whose name I dont have to hand right now) in a woman's vagina will also predict whether they have freckles or not. Biology is a fascinating subject and very much open to debate.
- astrange 5y ago
  > Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. Humans are very good at detecting rancid milk from the smell; I believe nobody's developed a machine better than us yet.
- JohnBooty 5y ago
  Japanese people claim to be able to smell gone off milk oozing from the pores of westerners. Not just Japanese who claim this; I've heard this from non-Japanese Asians as well. I think I remember hearing that there were some specific derogatory terms for Westerners based on this smell, but I could be wrong.

metadat 5y ago

Are you able to elaborate on this? I take a lot of anti-histamines and haven't noticed any difference other than it helps me medically. But I'd like to be on the lookout so I can be my best self.

antics9 5y ago
I second this. I take antihistamines from April to September. Loratadin absolutely has a negative effect on my mood. Mostly because I feel tired I believe. Switched to Ebastin and no more tiredness. However, I am starting to suspect that it also does affect my mood in some way or another. During winter I take a pill as a precautionary if I’m going to be in any dusty spaces. The day after I sometimes experience mood swings that I cannot explain.
- whatshisface 5y ago
  I have found that n95 masks work wonderfully for working in dusty spaces. A dividend of the pandemic I suppose.
  - selectodude 5y ago
    They sell 3M N95 masks at Home Depot for a reason :)
- throwaway2331 5y ago
  Have you tried mast-cell stabilizers? Ketotifen is one (albeit, still an antihistamine).
- heavyset_go 5y ago
  Levocetirizine doesn't cross the blood-brain barrier like other antihistamines such as loratadine does.
Terry_Roll 5y ago
It increases IQ, histidine, a precursor for histamine, doubled the IQ of people with downs syndrome in an experiment over several months, but histamine also increases aggression which probably explains why you dont see many aggressive people with Down Syndrome. Aged food & drink is higher in histamine. Red wine more than white wine. Dark spirits more than clear spirits. Red meat more than white meat. It can cause spontaneous erections, 60mg of histamine can be used for erectile dysfunction. Histamine can increase blood saturation levels and help reduce the symptoms of COPD and other respiratory problems. If you consumed alot of histadine, like several heaped table spoons with meals throughout the day, depending on your age and health you will notice some or all of the above. Its one of the fastest amino acids into muscle, its untouched by the liver. I dont know why you are taking anti-histamines, histamine helps the white immune cells move through tissue, it causes inflammation, there is also a histamine feedback loop in the brain which affects sleep patterns, which is why anti-histamines can help people get to sleep, but lots of histamine can improve sleep conversely. Loads of studies exist that can be found on Google Scholar, but multiple chemicals affect peoples personality, and their health. If you want to read up on this, also look at the pathways and other chemicals which work with histidine (or any other amino acid) for that matter.

cplusplusfellow 5y ago

Can you expound upon this? As someone with severe allergies I tend to take quite a bit of antihistamines.

nick__m 5y ago
An old antihistamine¹ was used as the blueprint for development of the first commercialized SSRI. Similar first generation antihistamines² also have a significant effect on SERT (serotonin transporter). Reciprocly, the weight gain induced by certain SSRI is tought to be caused by an antihistaminic effect³. It would not be surprising if other antihistamines (at least those that cross the BBB) had similar effects because antihistamines are frequently promiscuous (i.e. they have significant affinities with a lots of targets other than the one that make a drug effective) but I would be surprised if histamine, or its inhibition, was directly (with the exclusion of the miserable feeling that comes with allergies) implicated in moods changes. 1- https://en.wikipedia.org/wiki/Brompheniramine https://en.wikipedia.org/wiki/Brompheniramine 2- https://en.wikipedia.org/wiki/Chlorphenamine https://en.wikipedia.org/wiki/Chlorphenamine 3- https://pubmed.ncbi.nlm.nih.gov/27593622 https://pubmed.ncbi.nlm.nih.gov/27593622

captainoats 5y ago

Mirtazapine is a great example of this and can have profound effects on behavior