Though Krita[1] insists on advertising itself as a "painting program", it handles everything you listed: CMYK support,[2] color separation,[3] and non-destructi

Though Krita[1] insists on advertising itself as a "painting program", it handles everything you listed: CMYK support,[2] color separation,[3] and non-destructive editing.[4] Krita supports both raster and vector layers as well. It's well-suited for graphic design, and its interface is more familiar to Adobe product users. [1] https://krita.org https://krita.org [2] https://docs.krita.org/en/general_concepts/colors/color_models.html#cmyk https://docs.krita.org/en/general_concepts/colors/color_mode... [3] https://docs.krita.org/en/reference_manual/separate_image.html https://docs.krita.org/en/reference_manual/separate_image.ht... [4] https://docs.krita.org/en/user_manual/layers_and_masks.html#masks-and-filters https://docs.krita.org/en/user_manual/layers_and_masks.html#...