3 ms·
What is the better measurement, % of total administered dose or the ug/g concentration? The latter shows a relatively high does for some organs, particularly li
by bumby 5y ago
What is the better measurement, % of total administered dose or the ug/g concentration? The latter shows a relatively high does for some organs, particularly liver, spleen, and ovaries. As a layman, it seems like the latter would be the better metric as it's a normalized value but I assume you chose the former for a valid reason.
- jart 5y agoI'd rather see number of nanoparticles per cell. There's about 300,000 eggs in an ovary and 300 are ovulated in a lifetime. Eggs are cells and cells weigh 1 nanogram each. Virus particles weigh less than a femtogram. I assume the same applies to these lipid nanoparticles. So by my calculation that would be 123 lipid nanoparticles for each cell in the ovaries. `1e-9 / (0.1e-3 * 1e-12) * (12.3e-6)`. Pfizer's drug works by programming cells to produce spike proteins on the membrane so that the immune system recognizes them as the enemy and destroys them. I wish I knew why Pfizer needed to choose a delivery method for their drug that crosses the blood brain barrier and accumulates a 10x concentration in the ovaries. Since modern delivery technologies are so advanced that they should have been able to do something less systemic.