4 ms·

Maybe. Here's a skeptical view: "Despite a large number of studies, the overall quality of evidence for adverse effects of long-term use of PPIs is low to very

• jonathan-adly 5y ago
  10 years ago, as a young post-grad I spent a ridiculous amount of hours analyzing ALL the published peer-reviewed literature on the pros/cons of PPI prophylaxis for CVD patients and published my results in a peer reviewed article. I am literally the expert in that topic lol. Here is a nice paper[0] by Adly (me!), et al. I am biased, but I find it to be very comprehensive (and an excellent cure for insomnia!) [0]: https://pubmed.ncbi.nlm.nih.gov/23386069/ https://pubmed.ncbi.nlm.nih.gov/23386069/
  • sizzle 5y ago
    Awesome, what else can you teach us about PPI that isn’t mainstream knowledge
• phnofive 5y ago
  On the other hand, it has been linked to much higher rates of autoimmunities: https://doi.org/10.3389/fimmu.2021.736036 https://doi.org/10.3389/fimmu.2021.736036
  • allturtles 5y ago
    Many of those autoimmune disorders cause pain and inflammation. And many pain relievers and anti-inflammatories can cause damage to the stomach lining, which leads to a prescription for a PPI. I don't see any accounting for this possibility in the paper (that ADs cause PPIs, rather than vice versa).