3 ms·

Using PPIs for a short duration is safe, using PPIs chronically is not safe and the risks have to be weighted very carefully. It's by far the most intervened on

Using PPIs for a short duration is safe, using PPIs chronically is not safe and the risks have to be weighted very carefully. It's by far the most intervened on medications by clinical pharmacists (usually discontinuing for inappropriate use)

allturtles 5y ago
Maybe. Here's a skeptical view: "Despite a large number of studies, the overall quality of evidence for adverse effects of long-term use of PPIs is low to very low." [0] [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463334/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463334/
- jonathan-adly 5y ago
  10 years ago, as a young post-grad I spent a ridiculous amount of hours analyzing ALL the published peer-reviewed literature on the pros/cons of PPI prophylaxis for CVD patients and published my results in a peer reviewed article. I am literally the expert in that topic lol. Here is a nice paper[0] by Adly (me!), et al. I am biased, but I find it to be very comprehensive (and an excellent cure for insomnia!) [0]: https://pubmed.ncbi.nlm.nih.gov/23386069/ https://pubmed.ncbi.nlm.nih.gov/23386069/
  - sizzle 5y ago
    Awesome, what else can you teach us about PPI that isn’t mainstream knowledge
- phnofive 5y ago
  On the other hand, it has been linked to much higher rates of autoimmunities: https://doi.org/10.3389/fimmu.2021.736036 https://doi.org/10.3389/fimmu.2021.736036
  - allturtles 5y ago
    Many of those autoimmune disorders cause pain and inflammation. And many pain relievers and anti-inflammatories can cause damage to the stomach lining, which leads to a prescription for a PPI. I don't see any accounting for this possibility in the paper (that ADs cause PPIs, rather than vice versa).