MsMpEng.exe is the core component, not sure if you can just delete it. There's group policy setting for disabling it (and corresponding registry key, HKEY_LOCAL

MsMpEng.exe is the core component, not sure if you can just delete it. There's group policy setting for disabling it (and corresponding registry key, HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender\DisableAntiSpyware), but I think it only sticks in Enterprise versions.