https://en.wikipedia.org/wiki/Cannabis_use_disorder https://en.wikipedia.org/wiki/Cannabis_use_disorder Prolonged cannabis use produces both pharmacokinetic ch

https://en.wikipedia.org/wiki/Cannabis_use_disorder https://en.wikipedia.org/wiki/Cannabis_use_disorder Prolonged cannabis use produces both pharmacokinetic changes (how the drug is absorbed, distributed, metabolized, and excreted) and pharmacodynamic changes (how the drug interacts with target cells) to the body. These changes require the user to consume higher doses of the drug to achieve a common desirable effect (known as a higher tolerance), reinforcing the body's metabolic systems for eliminating the drug more efficiently and further down-regulating cannabinoid receptors in the brain.[7] Cannabis users have shown decreased reactivity to dopamine, suggesting a possible link to a dampening of the reward system of the brain and an increase in negative emotion and addiction severity.[8] (...) Cannabis withdrawal symptoms occur in one-half of people in treatment for cannabis use disorders.[15] Symptoms may include dysphoria (anxiety, irritability, depression, restlessness), disturbed sleep, gastrointestinal symptoms, and decreased appetite. It is often paired with rhythmic movement disorder. Most symptoms begin during the first week of abstinence and resolve after a few weeks.