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Different manufacturers use different compounds at different concentrations. What do you mean "you can't switch"? Plenty of people are getting moderna boosters

• tsol 5y ago
  What I meant is you won't develop separate antibody responses to each individual vaccine. You can mix and match the initial vaccine and boosters, and it'll strengthen your immune response. You just can't switch and expect the same response as someone taking that particular vaccine for the first time
  • netizen-936824 5y ago
    >separate antibody responses Of course not, they use the same mRNA. There's no reason to suspect they would in the first place. The difference in response in the degree/intensity of response to the detected antigen. This is due to the concentration of mRNA in the vaccine (and therefore the concentration of antigen produced by the vaccine) Moderna creates a greater response than Pfizer due to concentration (100mcg vs 30mcg). I don't think there's a reason to believe that a moderna booster on top of a Pfizer initial vaccination would not increase the degree of response when an actual infection is detected. Immunology is not my field however so my knowledge is a bit limited.