I don't know if these issues have been fixed but here's a study that looked into all types of animal studies for cancer for an overview and suggested fixes and

I don't know if these issues have been fixed but here's a study that looked into all types of animal studies for cancer for an overview and suggested fixes and listed notable failures. There is one study here that showed a promising cancer treatment in mice used at 500x dilution in humans and it caused systemic organ failure in humans. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/