4 ms·

Yes, it's 'in mice'. Where else should we study this? Should we study these effects on prisoners, military personnel, government workers, or school children?

Yes, it's 'in mice'. Where else should we study this? Should we study these effects on prisoners, military personnel, government workers, or school children? Perhaps those with this 'in mice' attitude think we should raise primates for these purposes? Mice are not the best model for humans, just like a Representative Democracy isn't the best model for a government. These things are, however, the best we have at this point in time. This is a great study as it conclusively proves not that sugar diets are bad, but HOW they are bad, and WHY they are bad. Sucrose is shown to interrupt key systems in the brain and now we have a model of how this occurs. Now we can try to image human brains that are suffering from these psychosis and we'll know better where to start our investigations. This is a good study with many implications for future human health studies. Great work.

ivalm 5y ago
When people start getting 2/3rd of their calories from sucrose..
- imchillyb 5y ago
  > When people start getting 2/3rd of their calories from sucrose.. @ivalm I don't think you understand how scientific studies are performed. Inducing change is what the study is accomplishing. Monitoring the changes and what changes occur is what the study sets out to document. Both of those goals are accomplished in the study. Correlations between schizophrenia and bipolar disorder patients with high glucose mice brains were readily recognized. Science isn't a god. Science is a method of study. We follow the method so that others may perform the same experiments in the future and reach similar conclusions, for proofs. The methods we use for testing such things have been in place for decades now, and they've served us well. If you don't understand why mice models are utilized, and why testing is done with such high percentages, then perhaps you should read more into pharmaceutical testing and development. Like I said, we've been doing this for decades now, and it serves us well.
  - ivalm 5y ago
    I’m no against mice models, but I do think that relationship between amount and outcome are important and non-linear and what happens when 2/3rd of your calories come from something is not indicative of an effect when you consume a smaller percentage. That said, your ad hominem attacks on me are not appreciated, do better.

ivalm 5y ago

When people start getting 2/3rd of their calories from sucrose..

imchillyb 5y ago
> When people start getting 2/3rd of their calories from sucrose.. @ivalm I don't think you understand how scientific studies are performed. Inducing change is what the study is accomplishing. Monitoring the changes and what changes occur is what the study sets out to document. Both of those goals are accomplished in the study. Correlations between schizophrenia and bipolar disorder patients with high glucose mice brains were readily recognized. Science isn't a god. Science is a method of study. We follow the method so that others may perform the same experiments in the future and reach similar conclusions, for proofs. The methods we use for testing such things have been in place for decades now, and they've served us well. If you don't understand why mice models are utilized, and why testing is done with such high percentages, then perhaps you should read more into pharmaceutical testing and development. Like I said, we've been doing this for decades now, and it serves us well.
- ivalm 5y ago
  I’m no against mice models, but I do think that relationship between amount and outcome are important and non-linear and what happens when 2/3rd of your calories come from something is not indicative of an effect when you consume a smaller percentage. That said, your ad hominem attacks on me are not appreciated, do better.