I guess my underlying question is whether or not some areas of research should just be absolutely off-limits. MKUltra, for example. Other human experimentation

I guess my underlying question is whether or not some areas of research should just be absolutely off-limits. MKUltra, for example. Other human experimentation. What if a physicist discovered the math to create black holes and wanted to test it; could any theoretical benefit be worth the known risk? Maybe it can be justified if the experiment is done in deep space, far from earth. Perhaps the same is true of gain of function, it should be studied on a moon facility instead of in or near a densely populated city? On the other hand, the highest form of safety is not doing it in the first place, which happens to be cheap compared to a moon base.