Considering the current political climate between US and china, supporting a non-lab origin is slowly becoming the contrarian idea. I wonder if the authors dis

Considering the current political climate between US and china, supporting a non-lab origin is slowly becoming the contrarian idea. I wonder if the authors discuss the evolution of the virus since it was first leaked/mutated. For example , eventhough it is believed, as the authors say, furin cleavage is a key to the virus' transmissibility, a computational study of the Omicron variant suggests the furin cleavage site has evolved for less efficient replication of the virus[1] (but still more transmissible due to immunity escape). beyond the flashy politics, the lab leak hypothesis is terrifying as it means that someone can create a worldwide crisis by doing relatively well understood modifications to existing viruses, and the world is clearly not prepared for such biodefense attacks. We should be talking about the day-after covid and what measures we need to prevent such rapid worldwide spread of pathogens. [1] https://www.biorxiv.org/content/10.1101/2021.12.14.472704v1.full https://www.biorxiv.org/content/10.1101/2021.12.14.472704v1....