Probably not. But I’m guessing that the people who created LuaTeX prefer Lua. And maybe, if you wanted to create a scriptable TeX that would be usable by the ty

Probably not. But I’m guessing that the people who created LuaTeX prefer Lua. And maybe, if you wanted to create a scriptable TeX that would be usable by the typical TeX user, a language like Lua makes more sense than a Lisp. Those users tend to be scientists and mathematicians, and just anyone who needs to make good-looking documents; most are not familiar with Lisp and would find it more difficult to learn than Lua.