4 ms·

That's why I don't get why people get so happy about Omicron - we know very little of the lasting damage from a "mild" infection! It's funny that people who are

That's why I don't get why people get so happy about Omicron - we know very little of the lasting damage from a "mild" infection! It's funny that people who are afraid of long-term effects from vaccines are not at all concerned by the long-term effects of an infection!

johnisgood 5y ago
What is the mechanism behind a mild, acute infection (as opposed to severe acute, or chronic) causing negative long-term effects? To phrase it differently: what is the mechanism behind "Long Covid"?
- deep-root 5y ago
  It would depend on which "long-term effects" you examine, they range from simple inflammation to brain damage[1]. Could be the virus causing damage or your own immune response. [1] https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/how-does-coronavirus-affect-the-brain https://www.hopkinsmedicine.org/health/conditions-and-diseas...
  - johnisgood 5y ago
    Sadly it does not seem to mention what MRI abnormalities there are, but I am very curious. Does it affect the white matter, for example? If so, which sites? Does it cause lesions? Demyelination, or what?
reindeer76 5y ago
>It's funny that people who are afraid of long-term effects from vaccines are not at all concerned by the long-term effects of an infection! I'm afraid of both. And since the vaccine doesn't prevent you from getting infected by omicron (actually, it seems it makes it worse, according to recent data), I reckon it's better to not get vaccinated and face one unknown source of long-term effects, instead of get vaccinated and face two unknown sources of long-term effects. How funny is that?
- jbd28 5y ago
  - dang 5y ago
    You've been repeatedly posting flamewar comments. We need you to stop that, regardless of how wrong other people are or you feel they are. It's not what this site is for, and it destroys what it is for, so we ban accounts that keep doing it. https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
- andrekandre 5y ago
  > it makes it worse, according to recent data have a link?
  - reindeer76 5y ago
    Denmark, Pfizer effectiveness against omicron of minus 75% (Table) https://www.medrxiv.org/content/10.1101/2021.12.20.21267966v3 https://www.medrxiv.org/content/10.1101/2021.12.20.21267966v... Scotland, similar https://www.pure.ed.ac.uk/ws/portalfiles/portal/245818096/Severity_of_Omicron_variant_of_concern_and_vaccine_effectiveness_against_symptomatic_disease.pdf https://www.pure.ed.ac.uk/ws/portalfiles/portal/245818096/Se... Strong negative vaccine effectiveness persists after controlling for age. Data are however uncontrolled for restrictions/behaviour, which might vary strongly in Europe. (unvaccinated people are excluded from full civil and social rights at the moment) The situation is unclear. As someone who is not at acute risk of Covid (age < 24, BMI < 24), there is absolutely no reason to be rushing to get these vaccines before the long-term effectiveness ad safety trials are over.
    - JimBlackwood 5y ago
      Nowhere in those papers does it mention having had a vaccination makes Omikron worse. The vaccines are just less effective. Big difference, please don’t spread false information.
deleted 5y ago
[deleted]

johnisgood 5y ago

What is the mechanism behind a mild, acute infection (as opposed to severe acute, or chronic) causing negative long-term effects? To phrase it differently: what is the mechanism behind "Long Covid"?

deep-root 5y ago
It would depend on which "long-term effects" you examine, they range from simple inflammation to brain damage[1]. Could be the virus causing damage or your own immune response. [1] https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/how-does-coronavirus-affect-the-brain https://www.hopkinsmedicine.org/health/conditions-and-diseas...
- johnisgood 5y ago
  Sadly it does not seem to mention what MRI abnormalities there are, but I am very curious. Does it affect the white matter, for example? If so, which sites? Does it cause lesions? Demyelination, or what?

reindeer76 5y ago

>It's funny that people who are afraid of long-term effects from vaccines are not at all concerned by the long-term effects of an infection! I'm afraid of both. And since the vaccine doesn't prevent you from getting infected by omicron (actually, it seems it makes it worse, according to recent data), I reckon it's better to not get vaccinated and face one unknown source of long-term effects, instead of get vaccinated and face two unknown sources of long-term effects. How funny is that?

jbd28 5y ago
- dang 5y ago
  You've been repeatedly posting flamewar comments. We need you to stop that, regardless of how wrong other people are or you feel they are. It's not what this site is for, and it destroys what it is for, so we ban accounts that keep doing it. https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
andrekandre 5y ago
> it makes it worse, according to recent data have a link?
- reindeer76 5y ago
  Denmark, Pfizer effectiveness against omicron of minus 75% (Table) https://www.medrxiv.org/content/10.1101/2021.12.20.21267966v3 https://www.medrxiv.org/content/10.1101/2021.12.20.21267966v... Scotland, similar https://www.pure.ed.ac.uk/ws/portalfiles/portal/245818096/Severity_of_Omicron_variant_of_concern_and_vaccine_effectiveness_against_symptomatic_disease.pdf https://www.pure.ed.ac.uk/ws/portalfiles/portal/245818096/Se... Strong negative vaccine effectiveness persists after controlling for age. Data are however uncontrolled for restrictions/behaviour, which might vary strongly in Europe. (unvaccinated people are excluded from full civil and social rights at the moment) The situation is unclear. As someone who is not at acute risk of Covid (age < 24, BMI < 24), there is absolutely no reason to be rushing to get these vaccines before the long-term effectiveness ad safety trials are over.
  - JimBlackwood 5y ago
    Nowhere in those papers does it mention having had a vaccination makes Omikron worse. The vaccines are just less effective. Big difference, please don’t spread false information.

deleted 5y ago

[deleted]