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I agree with the first part of what you said. (Note: I am an amateur Nutritional Geneticist) They said: "The results demonstrate that carriers of the genetic
by podgaj 5y ago
I agree with the first part of what you said.
(Note: I am an amateur Nutritional Geneticist)
They said:
"The results demonstrate that carriers of the genetic variation have what is known as sucrase-isomaltase deficiency, meaning that they have a peculiar way of metabolizing sugar in the intestine. Simply put, they do not absorb ordinary sugar in the bloodstream the way people without the genetic variation do. Instead, sugar heads directly into their intestine."
Ha! What? SI, the gene that they studied, ONLY exists in the intestine. The inability to break down sucrose leads to microbe imbalance that concerts the sucrose to acetate. They are using the word "sugar" to cover everything from sucrose to any other oligosaccaride. They just do not understand the science enough. If you read the study it is clear.
And in NO way doe sthis mean that eating sugar is healthy for them as the title implies!!!! Look at what happens when you have this deficiency!
https://medlineplus.gov/genetics/condition/congenital-sucrase-isomaltase-deficiency/ https://medlineplus.gov/genetics/condition/congenital-sucras...
"After ingestion of sucrose or maltose, an affected child will typically experience stomach cramps, bloating, excess gas production, and diarrhea. These digestive problems can lead to failure to gain weight and grow at the expected rate (failure to thrive) and malnutrition. "
So this is NOT a great mutation. There is no such thing as a universal "great" mutation. These genetic changes are just one change in a probably network of changes in the Inuit. Others would include genes like FADS1 and FADS2 and CPT1A.
(NOTE: I have Saami heritage, who are the Inuit of Finland.)
Next:
"'It is probably due to Greenlanders not having had very much sugar in their diet. For the most part, they have eaten meat and fat from fish, whales, seals and reindeer. A single crowberry may have crept in here and there, but their diet has had minimal sugar content,' "
Here the researchers are correct, this is not only a Greenlander trait, but a common trait in all Inuit, and very low sucrose is common in all Inuit diets.
https://pubmed.ncbi.nlm.nih.gov/25452324/ https://pubmed.ncbi.nlm.nih.gov/25452324/
And this absolutely is a fitness example. For people with the common allele, the lack of sucrose in the diet leads to lower levels of acetate and these people would die off leaving the survivors with the less common allele to flourish.
- phonypc 5y ago>And in NO way doe sthis mean that eating sugar is healthy for them as the title implies!!!! That's actually exactly what the study concludes. They say children do experience those symptoms, but adapt as adults and are better off for it.
- podgaj 5y agoThe study does not conclude that at all. They only concluded they might be able to trick some people to make money off a a drug they will make. Limitations: We hypothesize that the healthier metabolic profile observed in homozygous c.273_274delAG carriers was mediated by acetate produced by gut bacteria; however, we lack data to firmly verify this hypothesis. Impact: Our results suggest that sucrase-isomaltase constitutes a promising drug target for improvement of metabolic health, and in a broader perspective add to the debate about the health effects of sugar consumption. You know, it could be that these people are healthier because they avoid sugar because sugar makes them feel like crap when they get overloaded with aceatate. There is no evidence that higher levels of acetate are better for people. Because if that as so drinking would be healthy for everyone. https://academic.oup.com/alcalc/article-abstract/23/2/123/96577?redirectedFrom=fulltext https://academic.oup.com/alcalc/article-abstract/23/2/123/96... https://www.biorxiv.org/content/10.1101/2020.07.20.212597v1.full https://www.biorxiv.org/content/10.1101/2020.07.20.212597v1....
- phonypc 5y ago>You know, it could be that these people are healthier because they avoid sugar because sugar makes them feel like crap when they get overloaded with aceatate. They address that hypothesis and dismiss it. It's beyond my understanding to assess their methods, but don't pretend they didn't even mention it.
- podgaj 5y agoWhere did the study say that? They did the genetic study on mice, not humans. And they only said it gave them a better BMI, which is only one indicator of health.