3 ms·
Vaccine-derived immunity often outperforms immunity from natural infection. For COVID-19, it looks like this is true, but not by nearly as much as we'd like.
by mlyle 5y ago
Vaccine-derived immunity often outperforms immunity from natural infection. For COVID-19, it looks like this is true, but not by nearly as much as we'd like.
- headsoup 5y agoHow is that actually possible and not just completely variable across the board based on each individual's health? 'Often outperforms' leaves the question 'how often?'
- mlyle 5y ago> How is that actually possible and not just completely variable across the board based on each individual's health? 'Often outperforms' leaves the question 'how often?' That is, we know of many vaccines where the protection from vaccination is greater than the protection from prior infection. It looks like that is true of COVID vaccines, both by observational / case control data and from data comparing antibody neutralizing titers between convalescent plasma and vaccinated individuals.. e.g. https://cdn.jamanetwork.com/ama/content_public/journal/jama/938696/jld210021f1_1620430716.03243.png?Expires=1643331214&Signature=rz8bX-qJI3d7tkA5NEoxkkNRkng1o61I6BFjex8xJqgcCSt1x3GHNKXwlnuDTBGUgxqSzarDwB4qaL8lifemA5AZXAhRveLWD1vhphX~tierYtKPCo3xxvaKbs6iaAQnqwbCsne3rK0dn~xfrlTu8T77xTLhaW0BiE9raVb0Jxydve3P8aFGehxq5JGRURXt4~3EatE7eQAifu73Ri3PRHLFCldEPUSvNHVmsA-BvjCD9cbOsHgSP38ku-oT2PkoV4d~bZ7K5He4bLdnjUeCH1epOkHA~x30m2JIWcjDp~byTmhDTmCRB6he4Wu4omm8VkUfJUz8BhU4Bz4egbLzmQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA https://cdn.jamanetwork.com/ama/content_public/journal/jama/... For any given patient--- who knows. There could be one person somewhere who'd get no benefit from vaccination and a huge benefit from prior infection. We can only know about the superiority of vaccination to prior infection in aggregate, but the effect is real.