3 ms·
Nanopore sequencing is a really interesting technology. It utilizes fundamentally the same apparatus as a Coulter Counter [1], which is a general method of coun
by Cyclical 5y ago
Nanopore sequencing is a really interesting technology. It utilizes fundamentally the same apparatus as a Coulter Counter [1], which is a general method of counting and sizing arbitrary particles that's frequently used in flow cytometry. Applying it to sequencing by drawing unwound DNA through the pore was a really excellent logical leap, and we're only now starting to see the benefits of even though it was first ideated over 30 years ago.
[1] https://en.wikipedia.org/wiki/Coulter_counter https://en.wikipedia.org/wiki/Coulter_counter