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I do not like to be negative, but perhaps this book could be titled -- DNA seen through the eyes of a coder who does not know any biology. The genome is not a
by fastaguy88 5y ago
I do not like to be negative, but perhaps this book could be titled -- DNA seen through the eyes of a coder who does not know any biology.
The genome is not a computer program with lots of #ifdef's. It is a data store, much of which seems to be evolutionary left-overs, and a tiny fraction of which encodes the molecular machines that allow it to function. Depending on how you define decoding, perhaps less than 10% of the enzymes encoded by the genome (which are encoded by less than 0.2% of the genome) are involved in processing the genome data (DNA polymerase, RNA polymerase, ribosomal proteins, topoisomerase, etc). A larger fraction of enzymes are used to provide the energy and raw materials to keep the cell going, with an additional set of enzymes used for cell signaling. And much of the rest of the proteins in the cell (again, remembering that less than 2% of the human genome is protein coding) are used for structural purposes.
The genome has a large amount of potential information. In higher organisms and higher plants, a very small fraction (2-5%) of that data is evolutionarily conserved to the extent that we think we know what it does (many of us think the rest is literally evolutionary junk). The parts we understand encode molecular machines, but it takes a very broad definition of "code" to imagine that data is a program.
- PaulDavisThe1st 5y ago> It is a data store problem is, it's so, so so much more than a data store. There's no reason at this point, as we slowly come to understand more and more about DNA packing, structure, transcription control etc., to conclude that the non-coding parts are "junk".
- pablok2 5y agoThis. In addition to this, the complexity that each new biological system that's discovered adds to the entropy of the entire system. The classic mantra has been to explain away complexity with "evolution of the gaps" but this article is showing how this isn't even close to sufficient anymore.