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I used to be a network engineer but since becoming disabled with a familial genetic disorder 20 years ago (Autism, Bipolar Disorder, Hyperlipidemia) I decided t
by podgaj 5y ago
I used to be a network engineer but since becoming disabled with a familial genetic disorder 20 years ago (Autism, Bipolar Disorder, Hyperlipidemia) I decided to get my genetics and study its implication in my disorder.
I think the coding analogy is more quantum computing than anything we currently know, which is why the binary analogy seems to fail. It is computing but on a whole 'notha level. Quibit instead of Binary, or maybe something we are yet to understand.
The chief complaint I have about that article is that it does not even get into the fact that we actually have two genomes that are symbiotic; Our Nuclear Genome and out Mitochondrial Genome. Glad he did touch on the epigenetics however.
I do know that understanding your genetics at the level that I have can help you manage any unknown chronic condition. It turns out my mitochondrial genetics were much more important for me (I am pretty sure I have a Complex I deficiency, thought really a trait) and that a sort of mismatch with my Nuclear Genome (mostly Calcium, Potassium, and Sodium signalling) makes me very sensitive to my environment through oxidative stress signalling.
If you can see this complex dance you will appreciate just how wonderful and complex of a machine we are that we will never fully understand. In the end my cure is more art than science. More feeling than data.
Some examples that might bother you:
- Long Chain Omega 3 PUFAs are crucial to my health and I cannot eat short chain PUFAs for any extended period. This is due o my FADS1 and FADS2 genetics
- I am Electro-Hypersensitive. Exposure to household low frequency EMFs from wiring increases oxidative stress ion my body and causes me pain, insomnia, and mood disturbance. This is mainly from how EMFs trigger the Volatage Gated Ion Channels.
- Exposure to chemicals, which includes many medicines, triggers an immune reaction (drug induced Lupus) from the oxidative stress which is created through their metabolism by CYP450 enzymes.
I am able to remediate these issues by diet and environment changes and mostly through the supplements; Asocrbic Acid, Manganese, Zinc/Copper and P5P.
- Raaasmus 5y agoSo how much can I find out with my 700k rows of SNPs? Any resources you recommend?
- podgaj 5y agoIf you have your genome from 23andme; https://promethease.com/ https://promethease.com/ That is just a start, it is useful but incomplete. I usually end up searching for SNPs in my text file based on research I read. I made a bash program which I can use to run a bunch of SNPS of a specific gene. Oh, also: https://www.snp-nexus.org/v4/ https://www.snp-nexus.org/v4/ https://www.uniprot.org/ https://www.uniprot.org/ https://www.ncbi.nlm.nih.gov/snp/ https://www.ncbi.nlm.nih.gov/snp/ https://smpdb.ca/view/SMP0000017 https://smpdb.ca/view/SMP0000017 http://slc.bioparadigms.org/ http://slc.bioparadigms.org/
- corey_moncure 5y agoWhat practical steps did you take to go about investigating your own genome like this?
- freshpots 5y agoIt sure sounds like they spent a lot of time here: https://www.naturalnews.com/ https://www.naturalnews.com/
- podgaj 5y agoNo, actually not. I hate that website with all my being, and I hate all the naturopaths that spout nonsense about nutigenomics. I sat in on classes at UNC Chapel Hill and I only use peer reviews studies. If you want to challenge my knowledge please do so. I have spent 20 years doing this. I have a livelong disability and it runs in my family. NO one knows the cause but I am pretty sure it is mitochondrial and is largely affecting oxidative stress. https://pubmed.ncbi.nlm.nih.gov/20833242/ https://pubmed.ncbi.nlm.nih.gov/20833242/
- podgaj 5y agoIt is hard and it takes a long time. And I would not recommend it if you are not suffering from any chronic illnesses. Most people's disorders are due to diet/environment. A good place to start is uploading any data you have into https://promethease.com/ https://promethease.com/. I would ignore most of the "good" and "bad" results, I only used it to find rare SNPs that might be linked to my disorder. The best thing you can do is get your whole genome run. You can do it now for about $200.
- GordonS 5y ago> household low frequency EMFs from wiring increases oxidative stress ion my body and causes me pain, insomnia, and mood disturbance. This is mainly from how EMFs trigger the Volatage Gated Ion Channels Wow, I've never heard that before - do you have any good papers you can link to so I can read some more?
- freshpots 5y agoI am interested as well. They appear to be spouting off pseudoscience that sounds much better than the average person but I am open to seeing evidence otherwise.
- podgaj 5y agoMartin Pali is at the forefront of this but, you know, this is scary to a lot of people for some reason. The most studied ion channels are the Voltage Gated Calcium Ion Channels https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.12088 https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.12088 https://www.spandidos-publications.com/ijo/59/5/92 https://www.spandidos-publications.com/ijo/59/5/92 https://www.sciencedirect.com/science/article/abs/pii/S0143416003002057 https://www.sciencedirect.com/science/article/abs/pii/S01434... https://emmind.net/openpapers_repos/Applied_Fields-Hazads/Various_Effects/Various_Reviews/2021_Effects_of_electromagnetic_fields_on_neuronal_ion_channels_a_systematic_review.pdf https://emmind.net/openpapers_repos/Applied_Fields-Hazads/Va...
- podgaj 5y agoI have linked some papers in a response to another comment, but here is a youtube video: https://www.youtube.com/watch?v=0RIskTMLV40 https://www.youtube.com/watch?v=0RIskTMLV40 I feel the research is lacking on this because there is a large genetic component. I do not feel LF-EMFs are a danger to everyone, but certain people, like me, with gene changes in CACNA1C, might be more affected by LF-EMFs. It is no coincidence that CACNA1C is also linked to pretty much all the mood disorders. And I am in no way saying that LF-EMFs are the cause of all mood disorders.