5 ms·

It seems odd this is perceived as anti-aging rather than removing "zombie" cells from our body as a preventative measure that could be turned against us. This

It seems odd this is perceived as anti-aging rather than removing "zombie" cells from our body as a preventative measure that could be turned against us. This wouldn't stop the cell from "aging" and we still have aging-related issues like with memory degradation and other stuff that is not related to the zombie cells.

more_corn 5y ago
Rebranding it an anti-zombie vaccine would be metal.
- mkaic 5y ago
  "Yeah, stopped by for my Anti-Zombie booster shot at CVS on the way home today, feeling a little ill but looking forward to surviving the apocalypse. How was your day?"
  - codeddesign 5y ago
    “Sponsored by Monster Energy Drinks”
- kingcharles 5y ago
  What kind of metal? Zinc? Nickel? Hassium?
hinkley 5y ago
I'm worried we're going to find an epigenetic time bomb in destroying all senescent cells. These cells aren't just old, they remember our old life. Some adaptations to past trauma save us from further trauma. Others are more maladaptive. If this vaccine causes the immune system to 'forget' by killing off B cells, then you may have to get a booster shot for every vaccine you've ever had. That may not sound like a big deal but that creates a class division for longevity treatments. I could afford to take a month off, quarantine myself and get twenty booster shots. Some of my neighbors can't, so either they risk getting sick or they don't take the treatment at all. Science fiction has always asserted there would be class divisions in these sorts of treatments, so perhaps that's not a surprise.
- codeddesign 5y ago
  This is a little extreme. When was the last time you had to take a month off for a flu shot? Adults do this all the time when traveling overseas. It may be inconvenient to take a half day off to go to the clinic, but what you are saying is extreme. Not to mention, people take time off for augmentations and plastic surgery all the time.
  - hinkley 5y ago
    > When was the last time you had to take a month off for a flu shot? A flu shot? No. If you are traveling internationally they recommend getting your vaccinations a month in advance. Plus it's generally not the case that they want you to take every vaccination on the same day. If you had to be re vaccinated for everything you're currently required to go to school, you'd be taking DTap, Polio, Varicella, MMR, Hep A, Hep B, Hib, and probably Meningitis, and a couple of those take multiple doses. > Not to mention, people take time off for augmentations and plastic surgery all the time. Everyone, or upper and middle class?
- Symmetry 5y ago
  If a B cell becomes senescent it isn't going to be contributing contributing to your immune response in any event. In general a senescent cell represents a cell that failed at apoptosis when it was supposed to kill itself, going in and having the immune system finish the job won't hurt anything. That is, assuming that the vaccine works in humans and doesn't have unwanted side effects, which is very much a possibility at this stage.
  - hinkley 5y ago
    I think that depends on utility. If the senescent cells are functionally useless, then culling them should have few consequences (although your liver and kidneys might object to having that many cells being cleaned up at once). But if they are still sort of functioning in their primary or secondary functions (eg, structural integrity) then disappearing them all at once becomes a problem.
nomel 5y ago
To put it another way, this won't extend the Hayflick limit [1], so your cells will still die after the same number of divisions. 1. https://en.wikipedia.org/wiki/Hayflick_limit https://en.wikipedia.org/wiki/Hayflick_limit
- grishka 5y ago
  There's telomerase whose job is to lengthen telomeres. Telomere attrition is not irreversible.
  - nomel 5y ago
    Yes, and this vaccine is unrelated, which I believe was the grandparent comments point.
staticassertion 5y ago
"aging" is a complex set of a number of different issues. Cell senescence is generally considered to be an age related issue.

more_corn 5y ago

Rebranding it an anti-zombie vaccine would be metal.

mkaic 5y ago
"Yeah, stopped by for my Anti-Zombie booster shot at CVS on the way home today, feeling a little ill but looking forward to surviving the apocalypse. How was your day?"
- codeddesign 5y ago
  “Sponsored by Monster Energy Drinks”
kingcharles 5y ago
What kind of metal? Zinc? Nickel? Hassium?

hinkley 5y ago

I'm worried we're going to find an epigenetic time bomb in destroying all senescent cells. These cells aren't just old, they remember our old life. Some adaptations to past trauma save us from further trauma. Others are more maladaptive. If this vaccine causes the immune system to 'forget' by killing off B cells, then you may have to get a booster shot for every vaccine you've ever had. That may not sound like a big deal but that creates a class division for longevity treatments. I could afford to take a month off, quarantine myself and get twenty booster shots. Some of my neighbors can't, so either they risk getting sick or they don't take the treatment at all. Science fiction has always asserted there would be class divisions in these sorts of treatments, so perhaps that's not a surprise.

codeddesign 5y ago
This is a little extreme. When was the last time you had to take a month off for a flu shot? Adults do this all the time when traveling overseas. It may be inconvenient to take a half day off to go to the clinic, but what you are saying is extreme. Not to mention, people take time off for augmentations and plastic surgery all the time.
- hinkley 5y ago
  > When was the last time you had to take a month off for a flu shot? A flu shot? No. If you are traveling internationally they recommend getting your vaccinations a month in advance. Plus it's generally not the case that they want you to take every vaccination on the same day. If you had to be re vaccinated for everything you're currently required to go to school, you'd be taking DTap, Polio, Varicella, MMR, Hep A, Hep B, Hib, and probably Meningitis, and a couple of those take multiple doses. > Not to mention, people take time off for augmentations and plastic surgery all the time. Everyone, or upper and middle class?
Symmetry 5y ago
If a B cell becomes senescent it isn't going to be contributing contributing to your immune response in any event. In general a senescent cell represents a cell that failed at apoptosis when it was supposed to kill itself, going in and having the immune system finish the job won't hurt anything. That is, assuming that the vaccine works in humans and doesn't have unwanted side effects, which is very much a possibility at this stage.
- hinkley 5y ago
  I think that depends on utility. If the senescent cells are functionally useless, then culling them should have few consequences (although your liver and kidneys might object to having that many cells being cleaned up at once). But if they are still sort of functioning in their primary or secondary functions (eg, structural integrity) then disappearing them all at once becomes a problem.

nomel 5y ago

To put it another way, this won't extend the Hayflick limit [1], so your cells will still die after the same number of divisions. 1. https://en.wikipedia.org/wiki/Hayflick_limit https://en.wikipedia.org/wiki/Hayflick_limit

grishka 5y ago
There's telomerase whose job is to lengthen telomeres. Telomere attrition is not irreversible.
- nomel 5y ago
  Yes, and this vaccine is unrelated, which I believe was the grandparent comments point.

staticassertion 5y ago

"aging" is a complex set of a number of different issues. Cell senescence is generally considered to be an age related issue.