Tobacco has psychoactive substances besides nicotine. In particular, it has monoamine oxidase inhibitors, which are effective against depression, panic disorde

Tobacco has psychoactive substances besides nicotine. In particular, it has monoamine oxidase inhibitors, which are effective against depression, panic disorder, and social phobia. https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Some believe that this is why replacements that contain only nicotine (e.g. nicotine gum and patches) aren't really all that effective as smoking cessation aids.