3 ms·
That ‘just’ is doing a lot of work in the sentence, considering protein structure was/is often named as the “holy grail” of computational biology, and homology
by KarlKemp 5y ago
That ‘just’ is doing a lot of work in the sentence, considering protein structure was/is often named as the “holy grail” of computational biology, and homology was always the method to get there.
I’m equally skeptical of the claim that this follows the 80/20 (or 90/10) rule. If you use straightforward measurements (rmsd etc), reality may well be 10 % off considering these aren’t static structures, but molecules in perpetual chaotic motion on several scales.
- COGlory 5y ago>considering protein structure was/is often named as the “holy grail” of computational biology, and homology was always the method to get there Homology is never considered "solving the protein folding problem". It's 100% based off of past data which incorporates all sorts of biases, including as others have pointed out, experimental error. For instance, in my field, where there is terrible amino acid sequence conservation, AlphaFold is just as poor at prediction as existing solutions like Phyre.