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For those following - these treatments are 40 pill treatments. For the 50M odd cases we've had we'd need 40*50M pills (2 billion pills). Assume a daily global
by tempnow987 5y ago
For those following - these treatments are 40 pill treatments. For the 50M odd cases we've had we'd need 40*50M pills (2 billion pills).
Assume a daily global rate of around 600K cases per day we'd need 24M pills per day.
USA alone is perhaps 100K cases, so 4M pills per day. Do they really have this volume ready to go?
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I'm not aware of a single study showing that for vaccinated folks the pills do anything. Not saying they don't, but it would be helpful to have ONE study.
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As to why the FDA has not approved, they are reasonably clear. One issue is that COVID, and particularly omicron variant which dominates, is just not that lethal.
EDIT: This part is incorrect below
These pills work in interesting ways, ie, generating MORE mutations.
β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells https://pubmed.ncbi.nlm.nih.gov/33961695/ https://pubmed.ncbi.nlm.nih.gov/33961695/
So before you jam 2 billion doses into folks there is going to be a bit of an evaluation.
If Omicron turns out to have high fatality rates then I suspect things like these therapies will be fast tracked a bit more.
- tguvot 5y agoyou describing here merck treatment, not pfizers
- loeg 5y ago> For those following - these treatments are 40 pill treatments. > These pills work in interesting ways, ie, generating MORE mutations. > β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells https://pubmed.ncbi.nlm.nih.gov/33961695/ https://pubmed.ncbi.nlm.nih.gov/33961695/ You're way off-base. You're talking about Merck's Molnupiravir (Lagevrio), which is both less effective (~30% vs ~88%) and already approved. Pfizer's Paxlovid (Nirmatrelvir) is not mutagenic. It is a 15 pill course (5 days x 3 per day), not 40. Also, Pfizer thinks as of Nov 29 that they can make 80M courses by EOY. The US has purchased at least 10M of them.