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> We also have 80 years of experience with the flu vaccine opposed to 8 months 8 months is incorrect. Here's[1] an article from 17 months ago about results fro

> We also have 80 years of experience with the flu vaccine opposed to 8 months 8 months is incorrect. Here's[1] an article from 17 months ago about results from Moderna's covid-19 trials for vaccinations dating back to mar16 2020. So it's been 21 months, not 8 (and that's ignoring trials of mRNA vaccines years earlier as they weren't for this specific virus) [1] https://www.cidrap.umn.edu/news-perspective/2020/07/hopeful-results-phase-1-moderna-covid-vaccine-trial https://www.cidrap.umn.edu/news-perspective/2020/07/hopeful-...

s1artibartfast 5y ago
We can split hairs on what constitutes experience, or when it starts. but the point still stands: We have a lot more experience with the flu vaccine. This is the answer for why not all annual flu vaccines need clinical trials.
- ashildr 5y ago
  „the flu vaccine“? Which one?
  - s1artibartfast 5y ago
    The first vaccines in 1933 were against A type influenzas, followed by vaccines against against B type influenzas in 1942. Here is a pretty good summary of the history of vaccine development. https://www.medscape.com/viewarticle/812621_1 https://www.medscape.com/viewarticle/812621_1 While nearly all influenza vaccines generate similar antibodies, Covid and influenza vaccines generate significantly different antibodies Influenza vaccines generate antibodies against influenza Hemagglutinin proteins targeting sialic acid receptors Covid vaccines generate antibodies for (S) glycoproteins targeting ACE-2 receptors. In short, we have 80+ years of experience generating antibodies for hemagglutinin, and much less for (S) glycoproteins. https://en.wikipedia.org/wiki/Coronavirus_spike_protein https://en.wikipedia.org/wiki/Coronavirus_spike_protein https://en.wikipedia.org/wiki/Hemagglutinin_(influenza) https://en.wikipedia.org/wiki/Hemagglutinin_(influenza)

s1artibartfast 5y ago

We can split hairs on what constitutes experience, or when it starts. but the point still stands: We have a lot more experience with the flu vaccine. This is the answer for why not all annual flu vaccines need clinical trials.

ashildr 5y ago
„the flu vaccine“? Which one?
- s1artibartfast 5y ago
  The first vaccines in 1933 were against A type influenzas, followed by vaccines against against B type influenzas in 1942. Here is a pretty good summary of the history of vaccine development. https://www.medscape.com/viewarticle/812621_1 https://www.medscape.com/viewarticle/812621_1 While nearly all influenza vaccines generate similar antibodies, Covid and influenza vaccines generate significantly different antibodies Influenza vaccines generate antibodies against influenza Hemagglutinin proteins targeting sialic acid receptors Covid vaccines generate antibodies for (S) glycoproteins targeting ACE-2 receptors. In short, we have 80+ years of experience generating antibodies for hemagglutinin, and much less for (S) glycoproteins. https://en.wikipedia.org/wiki/Coronavirus_spike_protein https://en.wikipedia.org/wiki/Coronavirus_spike_protein https://en.wikipedia.org/wiki/Hemagglutinin_(influenza) https://en.wikipedia.org/wiki/Hemagglutinin_(influenza)