5 ms·

Out of curiosity, do we really require these studies? Like it is good to have more and more sources, but wouldn't the expected outcome to be the following: - v

Out of curiosity, do we really require these studies? Like it is good to have more and more sources, but wouldn't the expected outcome to be the following: - vaccines that replicated the spike protein will be less effective since omicron has a modified spike protein, because the immune system only was trained to notice the spike protein and not the payload - naturally induced immunity from prior exposure to Sars-Cov-2 will be more effective because the body made immunity to the payload alongside the total viral shape

SergeAx 5y ago
Yes, we need to know how severe the illness from this variant is. It was never a question of transmission. When we got news from Norway where 120 vaccinated negative tested people came into the restaurant for a couple of hours and at least 60 of them came out with positive omicron test - it became clear that we are fucked. Also, news from South Africa, where two people were quarantined in a hotel their rooms was across the corridor, and virus got from one to another, despite they never get out, just opened the door to take food and make tests. So it looks like everybody will have this variant in the next year, except maybe people in distant places. The question was how many will get seriously sick and how many of them will die. Looks like numbers will be lower than expected.
- vmception 5y ago
  Also meaning natural immunity faster, hopefully an underwhelming hospital load. Someone needs to check if masks and cloths over nose and face still have moderate effectiveness in densely populated areas.
oneoff786 5y ago
Do you really need to check the safety on your gun if you expect that it’s on?
- vmception 5y ago
  Going to definitely need you to explain that analogy though
  - oneoff786 5y ago
    Relying on a safety critical assumption to be true without checking it isn’t a good idea even if it’s probably true.
Nursie 5y ago
> naturally induced immunity from prior exposure to Sars-Cov-2 will be more effective This seems like a pretty big assumption TBH, and something that needs study. Is it better? How much? Why? How long does it last?
- Madmallard 5y ago
  There's a lot of research on it actually and ZDoggMD and Vinay Prasad MPH summarize it a bit in their latest collaboration.
redisman 5y ago
Who needs scientific research and data when you have the HN comments section
stjohnswarts 5y ago
The virus can only modify the spike protein so much before the spike protein won't work to infiltrate cells any longer and go extinct. It appears that the body is forgetting how to make antibodies rather quickly the vaccines are still pretty effective even against omicron if relatively recent or a booster has happened.
ramblerman 5y ago
You are right we don't need more studies, your hunch is sufficient.
- vmception 5y ago
  Need wasnt the word I was really thinking, more about having more people predict the expected outcome accurately there is fundamental knowledge involved here that colleges teach, and its good to know what the expected outcome is and how the studies conform to that expected outcome the studies are conforming to the expected outcome, which is good

SergeAx 5y ago

Yes, we need to know how severe the illness from this variant is. It was never a question of transmission. When we got news from Norway where 120 vaccinated negative tested people came into the restaurant for a couple of hours and at least 60 of them came out with positive omicron test - it became clear that we are fucked. Also, news from South Africa, where two people were quarantined in a hotel their rooms was across the corridor, and virus got from one to another, despite they never get out, just opened the door to take food and make tests. So it looks like everybody will have this variant in the next year, except maybe people in distant places. The question was how many will get seriously sick and how many of them will die. Looks like numbers will be lower than expected.

vmception 5y ago
Also meaning natural immunity faster, hopefully an underwhelming hospital load. Someone needs to check if masks and cloths over nose and face still have moderate effectiveness in densely populated areas.

oneoff786 5y ago

Do you really need to check the safety on your gun if you expect that it’s on?

vmception 5y ago
Going to definitely need you to explain that analogy though
- oneoff786 5y ago
  Relying on a safety critical assumption to be true without checking it isn’t a good idea even if it’s probably true.

Nursie 5y ago

> naturally induced immunity from prior exposure to Sars-Cov-2 will be more effective This seems like a pretty big assumption TBH, and something that needs study. Is it better? How much? Why? How long does it last?

Madmallard 5y ago
There's a lot of research on it actually and ZDoggMD and Vinay Prasad MPH summarize it a bit in their latest collaboration.

redisman 5y ago

Who needs scientific research and data when you have the HN comments section

stjohnswarts 5y ago

The virus can only modify the spike protein so much before the spike protein won't work to infiltrate cells any longer and go extinct. It appears that the body is forgetting how to make antibodies rather quickly the vaccines are still pretty effective even against omicron if relatively recent or a booster has happened.

ramblerman 5y ago

You are right we don't need more studies, your hunch is sufficient.

vmception 5y ago
Need wasnt the word I was really thinking, more about having more people predict the expected outcome accurately there is fundamental knowledge involved here that colleges teach, and its good to know what the expected outcome is and how the studies conform to that expected outcome the studies are conforming to the expected outcome, which is good