4 ms·

There's one approved drug that is probably effective against covid, Fluvoxamine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633915/ https://www.ncbi.nlm.nih.

There's one approved drug that is probably effective against covid, Fluvoxamine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633915/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633915/ Everyone knows Paxlovid is safe and effective too, but you aren't allowed to take it yet.

the_doctah 5y ago
"Everyone knows"? Paxlovid was submitted for emergency approval to the FDA just last month.
AnthonBerg 5y ago
Fluoxetine as well: "Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study" – https://pubmed.ncbi.nlm.nih.gov/34856085/ https://pubmed.ncbi.nlm.nih.gov/34856085/ "Do the Selective Serotonin Reuptake Inhibitor Antidepressants Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With COVID-19?" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786140 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786136 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "Mortality risk is confirmed to be significantly decreased among patients with #COVID-19 prescribed SSRI antidepressants, and particularly #fluoxetine, and fluoxetine or #fluvoxamine, in a large (n>80,000) US observational study." – https://twitter.com/HoertelN/status/1460309793558646785?s=20 https://twitter.com/HoertelN/status/1460309793558646785?s=20 Dr. Farid Jalali's track record on accuracy of statements on the pathophysiology is excellent. Here's a thread that outlines how and why SSRIs work to reduce illness in COVID: https://twitter.com/farid__jalali/status/1440876997182300169 https://twitter.com/farid__jalali/status/1440876997182300169 Platelets and serotonin are involved in the disease. Serotonin tends to cause inflammation, clotting, and vasoconstriction. A significant feature of COVID-19 is elevated plasma serotonin. (Here's an almost random source for this: https://twitter.com/ivanajpavlovic/status/1460712649176633347?s=20 https://twitter.com/ivanajpavlovic/status/146071264917663334... ... another: https://twitter.com/__ice9/status/1345194722055385091 https://twitter.com/__ice9/status/1345194722055385091 ... these are tweets, yes, but they link to papers.) Platelets have serotonin transporters and serotonin receptors. SARS-CoV-2 does a lot of things; One of the things it does is that it kills platelets by inducing necroptosis (source: https://twitter.com/DrKoupenova/status/1418558896390688776?s=20 https://twitter.com/DrKoupenova/status/1418558896390688776?s... ). This releases the serotonin inside them, causing other platelets to clot. SSRIs block platelets from picking up serotonin produced and secreted by enterochromaffin cells in the digestive tract; This is the source of the platelets' serotonin payload (more here: https://en.wikipedia.org/wiki/Enterochromaffin_cell https://en.wikipedia.org/wiki/Enterochromaffin_cell ). If an SSRI is taken early, platelets will have reduced serotonin payloads, which limits the serotonin-induced damage to the lung. I had no idea about any of this until recently. Another thing I had no idea about: Serotonin is metabolised by the lungs. https://twitter.com/ablative_sasha/status/1440162084285665286 https://twitter.com/ablative_sasha/status/144016208428566528... — and COVID-19 damages the lungs. It's a bad feedback loop involving way too much free serotonin. There are other things at play but this is one of them. SSRIs work for a lot of patients, have a significant and confirmed benefit, and a mechanism of action that makes sense. I've also seen pretty substantial claims / results that arginine, N-acetylcysteine, and melatonin seem to help. The best way to dig up those scientific results that do exist on it is actually to search Twitter for it. Try to find reliable-seeming scientists that are linking to actual papers and are careful in not suggesting too much.

the_doctah 5y ago

"Everyone knows"? Paxlovid was submitted for emergency approval to the FDA just last month.

AnthonBerg 5y ago

Fluoxetine as well: "Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study" – https://pubmed.ncbi.nlm.nih.gov/34856085/ https://pubmed.ncbi.nlm.nih.gov/34856085/ "Do the Selective Serotonin Reuptake Inhibitor Antidepressants Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With COVID-19?" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786140 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786136 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "Mortality risk is confirmed to be significantly decreased among patients with #COVID-19 prescribed SSRI antidepressants, and particularly #fluoxetine, and fluoxetine or #fluvoxamine, in a large (n>80,000) US observational study." – https://twitter.com/HoertelN/status/1460309793558646785?s=20 https://twitter.com/HoertelN/status/1460309793558646785?s=20 Dr. Farid Jalali's track record on accuracy of statements on the pathophysiology is excellent. Here's a thread that outlines how and why SSRIs work to reduce illness in COVID: https://twitter.com/farid__jalali/status/1440876997182300169 https://twitter.com/farid__jalali/status/1440876997182300169 Platelets and serotonin are involved in the disease. Serotonin tends to cause inflammation, clotting, and vasoconstriction. A significant feature of COVID-19 is elevated plasma serotonin. (Here's an almost random source for this: https://twitter.com/ivanajpavlovic/status/1460712649176633347?s=20 https://twitter.com/ivanajpavlovic/status/146071264917663334... ... another: https://twitter.com/__ice9/status/1345194722055385091 https://twitter.com/__ice9/status/1345194722055385091 ... these are tweets, yes, but they link to papers.) Platelets have serotonin transporters and serotonin receptors. SARS-CoV-2 does a lot of things; One of the things it does is that it kills platelets by inducing necroptosis (source: https://twitter.com/DrKoupenova/status/1418558896390688776?s=20 https://twitter.com/DrKoupenova/status/1418558896390688776?s... ). This releases the serotonin inside them, causing other platelets to clot. SSRIs block platelets from picking up serotonin produced and secreted by enterochromaffin cells in the digestive tract; This is the source of the platelets' serotonin payload (more here: https://en.wikipedia.org/wiki/Enterochromaffin_cell https://en.wikipedia.org/wiki/Enterochromaffin_cell ). If an SSRI is taken early, platelets will have reduced serotonin payloads, which limits the serotonin-induced damage to the lung. I had no idea about any of this until recently. Another thing I had no idea about: Serotonin is metabolised by the lungs. https://twitter.com/ablative_sasha/status/1440162084285665286 https://twitter.com/ablative_sasha/status/144016208428566528... — and COVID-19 damages the lungs. It's a bad feedback loop involving way too much free serotonin. There are other things at play but this is one of them. SSRIs work for a lot of patients, have a significant and confirmed benefit, and a mechanism of action that makes sense. I've also seen pretty substantial claims / results that arginine, N-acetylcysteine, and melatonin seem to help. The best way to dig up those scientific results that do exist on it is actually to search Twitter for it. Try to find reliable-seeming scientists that are linking to actual papers and are careful in not suggesting too much.