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It's an odd protein they're hitting - GPMNB is expressed pretty widely, so I wonder what the proteoform is that they're targeting/recognising here. Can't get t
by hirenj 5y ago
It's an odd protein they're hitting - GPMNB is expressed pretty widely, so I wonder what the proteoform is that they're targeting/recognising here.
Can't get to the paper using all the usual tricks, so it's hard to say what exactly they're immunising with, which could answer a lot of my questions.
- narrator 5y agoGPMNB seems to be expressed in cancer cells. Cancer cells are usually kind of screwed up and senescent. Maybe it's one of those little anti-cancer Rube Goldberg machines like p53 that starts popping off triggering apoptosis when things get weird in the cell.