You can definitely do this, but at a very large cost in sound quality. Most instruments that you're trying to emulate have timbre that varies widely across the

You can definitely do this, but at a very large cost in sound quality. Most instruments that you're trying to emulate have timbre that varies widely across their frequency range. A piano key on the left side of the keyboard sounds very different from a piano key on the right side recorded and pitched down. This is why sample-based instruments are generally multisampled. It's not to avoid resampling, which is generally efficient and sounds good. It's to accommodate timbre changes.