I feel that there are definitely some areas where currently-available technology is not being fully exploited - things like calculating the weight and center-of

I feel that there are definitely some areas where currently-available technology is not being fully exploited - things like calculating the weight and center-of-gravity position (would it measurably increase any sort of risk to put a load cell in each strut of the undercarriage?), checking the parking brake is off when accelerating above taxiing speed, and calling for an abort, before it is too late, if the acceleration on takeoff is insufficient. The inverse of your "all systems nominal" light exists, in many if not all commercial airplanes of any size, in the form of the master caution and master warning lights, but you also need to know what, specifically, is going wrong.