If you are really concerned about flux and lead I would suggest using a lead-free solder with a good (i.e. not the cheap on with "active charcoal filters") fume

If you are really concerned about flux and lead I would suggest using a lead-free solder with a good (i.e. not the cheap on with "active charcoal filters") fume hood. As far as handling leaded PCB goes I really don't see it as being an issue unless you voluntarily lick it, and even then I am not sure that there would be nefarious consequences (aside from probably getting sick from leftover flux). What I do is just use leaded solder but wash my hands afterwards. I solder about every two weeks so I just don't think it would even show up in a blood work. I don't have children but I suppose you can just lock your supplies somewhere or educate them depending on their age.