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If someone could answer my question with a logical response instead of just down voting it I would appreciate it because it is a serious question I am trying to
by podgaj 5y ago
If someone could answer my question with a logical response instead of just down voting it I would appreciate it because it is a serious question I am trying to understand about the vaccines. I am debating on getting a booster but I have a risk profile that makes this more of an issue for me.
So, what was the science behind the different doses? Does anyone know if Pfizer and Moderna used different mRNA?
- jrk 5y agoThey did not use the exact same mRNA sequence: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273/blob/main/Assemblies%20of%20putative%20SARS-CoV2-spike-encoding%20mRNA%20sequences%20for%20vaccines%20BNT-162b2%20and%20mRNA-1273.docx.pdf https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV... The different doses were guesses made to balance effectiveness with severity of side effects. (Earlier Moderna trials, at least, had included even higher doses, which could cause pretty severe side effects.) Their choices had to be locked in early, based on very limited preliminary trial data, in order to run their phase 3 trials as quickly as possible, to actually bring the vaccines to market quickly in 2020. They just made somewhat different bets. I think it's as simple as that.
- repler 5y agoNYTimes has some pretty great explainers: https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html https://www.nytimes.com/interactive/2020/health/moderna-covi... https://www.nytimes.com/interactive/2020/health/pfizer-biontech-covid-19-vaccine.html https://www.nytimes.com/interactive/2020/health/pfizer-biont... I don't think they are paywalled. Worth a read.