4 ms·
According to this source https://www.statnews.com/2021/02/02/comparing-the-covid-19-vaccines-developed-by-pfizer-moderna-and-johnson-johnson/ https://www.statne
by cure 5y ago
According to this source https://www.statnews.com/2021/02/02/comparing-the-covid-19-vaccines-developed-by-pfizer-moderna-and-johnson-johnson/ https://www.statnews.com/2021/02/02/comparing-the-covid-19-v... the original Pfizer dose was 30 micrograms of vaccine, while Moderna's was 100 micrograms.
If that is correct, then Moderna's booster would still be more vaccine (50 micrograms) than Pfizer's original dose.
Of course more is not necessarily better!
- userbinator 5y agoOne wonders if another full dose of Moderna would provide even better protection, given that a correlation has been found with the dosage: https://news.ycombinator.com/item?id=28580745 https://news.ycombinator.com/item?id=28580745
- Enginerrrd 5y agoIt almost certainly would. But with all vaccines, there is a balance between enough and too much immune response.
- gonehome 5y agoThough in this case I suspect more was better. At least that’s my hypothesis for why moderna vaccine immunity held up better against delta than Pfizer
- pseudalopex 5y agoModerna had more time between doses too.
- sjg007 5y ago3 Pfizers is basically 1 moderna...
- podgaj 5y agoThinking seriously about this, I will ask, were these different dosages a work of collusion between these companies and the government because they were so unsure of the reaction and efficacy at a specific dose? Was it, in effect, a huge "clinical trial"? Between Pfizer and Moderna what is the difference other than dose? Didn't they use the same mRNA? So what was the science behind them choosing different doses? Were they guessing or were they colluding?
- podgaj 5y agoIf someone could answer my question with a logical response instead of just down voting it I would appreciate it because it is a serious question I am trying to understand about the vaccines. I am debating on getting a booster but I have a risk profile that makes this more of an issue for me. So, what was the science behind the different doses? Does anyone know if Pfizer and Moderna used different mRNA?
- jrk 5y agoThey did not use the exact same mRNA sequence: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273/blob/main/Assemblies%20of%20putative%20SARS-CoV2-spike-encoding%20mRNA%20sequences%20for%20vaccines%20BNT-162b2%20and%20mRNA-1273.docx.pdf https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV... The different doses were guesses made to balance effectiveness with severity of side effects. (Earlier Moderna trials, at least, had included even higher doses, which could cause pretty severe side effects.) Their choices had to be locked in early, based on very limited preliminary trial data, in order to run their phase 3 trials as quickly as possible, to actually bring the vaccines to market quickly in 2020. They just made somewhat different bets. I think it's as simple as that.
- repler 5y agoNYTimes has some pretty great explainers: https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html https://www.nytimes.com/interactive/2020/health/moderna-covi... https://www.nytimes.com/interactive/2020/health/pfizer-biontech-covid-19-vaccine.html https://www.nytimes.com/interactive/2020/health/pfizer-biont... I don't think they are paywalled. Worth a read.