3 ms·
What do you mean by alignment being probabilistic? If you mean that some reads align faster and you could game the system, then perhaps we should tie the system
by teekert 5y ago
What do you mean by alignment being probabilistic? If you mean that some reads align faster and you could game the system, then perhaps we should tie the system to hospital based verification of the input data.
Ie, hospital publishes sequencing data (perhaps using fully homomorphic encryption to keep this very sensitive data private), someone aligns it, someone (or the hospital) verifies it, aligner gets paid coin.
The verification of the alignment being easier than the alignment itself is analogous to blockchain verification being easier than actually signing a block, right?
- jghn 5y agoNot quite the best phrase I'll admit. It's identifying the best fit. That's not the same as identifying truth. For instance, my recollection is that bwa-mem has (had?) some small amount of nondeterminism in it.
- teekert 5y agoAh yes, it would be easy to confirm a good alignment, identifying if any alignment is the best there is would be more difficult I guess, indeed.