11 ms·
Is "First Shot" "Second Shot" and "Booster" the same as 3 "doses"?
by fractal618 5y ago
Is "First Shot" "Second Shot" and "Booster" the same as 3 "doses"?
- IgorPartola 5y agoYes.
- bmitc 5y agoAccording to the CVS person who did my booster, the booster for Pfizer is a full dose while the Moderna booster is a half dose (relative to each manufacturer's original first and second shot doses).
- jsiepkes 5y agoWorth noting that Moderna uses a larger dosis then Pfizer for the first and second shot.
- syntaxing 5y agoAnd at half dose of Moderna is still larger than a full dose of Pfizer
- prox 5y agoProbably because Moderna’s original shot was already a higher dosage than Pfizers.
- cure 5y agoAccording to this source https://www.statnews.com/2021/02/02/comparing-the-covid-19-vaccines-developed-by-pfizer-moderna-and-johnson-johnson/ https://www.statnews.com/2021/02/02/comparing-the-covid-19-v... the original Pfizer dose was 30 micrograms of vaccine, while Moderna's was 100 micrograms. If that is correct, then Moderna's booster would still be more vaccine (50 micrograms) than Pfizer's original dose. Of course more is not necessarily better!
- userbinator 5y agoOne wonders if another full dose of Moderna would provide even better protection, given that a correlation has been found with the dosage: https://news.ycombinator.com/item?id=28580745 https://news.ycombinator.com/item?id=28580745
- Enginerrrd 5y agoIt almost certainly would. But with all vaccines, there is a balance between enough and too much immune response.
- gonehome 5y agoThough in this case I suspect more was better. At least that’s my hypothesis for why moderna vaccine immunity held up better against delta than Pfizer
- pseudalopex 5y agoModerna had more time between doses too.
- sjg007 5y ago3 Pfizers is basically 1 moderna...
- podgaj 5y agoThinking seriously about this, I will ask, were these different dosages a work of collusion between these companies and the government because they were so unsure of the reaction and efficacy at a specific dose? Was it, in effect, a huge "clinical trial"? Between Pfizer and Moderna what is the difference other than dose? Didn't they use the same mRNA? So what was the science behind them choosing different doses? Were they guessing or were they colluding?
- podgaj 5y ago
- junon 5y agoYes. Admittedly a weird way of communicating it but I think they're trying to accommodate those who are already confused. I personally think it's having the opposite effect.
- BiteCode_dev 5y agoI wager it's more to avoid the "what, a 3rd dose?" reaction. "Booster" is more positive than "we told you it would be immunization, but actually it's partial and limited, and you have to do it again. Woops, now again". Especially since people have been talking about a 4th dose. In the context of distrust of the pharma industry, it would be easy to have the social networks to claim pfizer is trying to become the netflix of vaccine and sell shots as a service. So they are very careful with the wording.
- Enginerrrd 5y agoBooster is also established immunology nomenclature that perfectly fits the situation, I don't think it's an attempt to "spin" it.
- snovv_crash 5y agoWell, it was effective as promised against the strains it was marketed as effective against. Those strains have been effectively eradicated. The issue is Delta, and now Omicron, which developed after the vaccine was designed.
- Thiez 5y agoThey also said the vaccine targeted the spike protein, which was said to be very unlikely to mutate since it's such a vital part of the virus and there is little room for variation.
- seoaeu 5y agoUnlikely to mutate much. The vaccine still remains effective because the new variants still have very similar spike proteins