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Katalin Karikó's 2005 paper provides some insight into a few of the stranger aspects of RNA's interaction with the immune system. You can't just put all RNA, o
by harshreality 5y ago
Katalin Karikó's 2005 paper provides some insight into a few of the stranger aspects of RNA's interaction with the immune system. You can't just put all RNA, or even all mRNA, in a bucket and consider it all the same. Slight variations can change biochemical reactivity activating or avoiding an immune response.
https://doi.org/10.1016/j.immuni.2005.06.008 https://doi.org/10.1016/j.immuni.2005.06.008
- thehappypm 5y agoI get chills reading that paper. I know that without mRNA vaccines we’d have plenty of alternatives, but for a while there it was really saving the world.
- Turing_Machine 5y agoWhat gives me chills is that she was denied tenure at the University of Pennsylvania. Fortunately she got a side gig, and managed to stay on as an adjunct. She was able to keep working on mRNA rather than having to be a waiter or an Uber driver or something like that. Now she's on just about everyone's short list for a Nobel Prize in the not-too-distant future.