3 ms·
Why can't they just test this hypothesis that Yersinia bacteria growing under refrigeration cause the symptoms? Simply culture a small amount of Yersinia, spre
by mrtnmcc 5y ago
Why can't they just test this hypothesis that Yersinia bacteria growing under refrigeration cause the symptoms?
Simply culture a small amount of Yersinia, spread it on a cracker and give it to a Chrohn's suscetiple person (and also placebo) and repeat with non-Chrohn people. The disease tends to have quick flare ups, so it should be easy to quickly draw a conclusion (unless they don't think flares are directly related).
- epgui 5y agoIt's almost guaranteed to not be caused by Yersinia exclusively. Many whole-microbiome sequencing studies have been done, and this would have come up if it were that simple. More likely, a mix of Yersinia and other species will be selected for. It does raise novel ideas for how to work with and interpret microbiome studies. I'd like to see microbiota in fecal samples be sequenced before and after a cold test, for example. But even then, you might not see any results. It could be a metabolomic problem more than a microbiome problem, or even more likely still, both combined with an immune repertoire problem and other dysregulations.