"once-in-a-lifetime" for an individual is more than 100 million (current US population divided into roughly 3 generations) times in aggregate over the course of

"once-in-a-lifetime" for an individual is more than 100 million (current US population divided into roughly 3 generations) times in aggregate over the course of a given generation (again, roughly speaking). What fraction of those is an acceptable death/disability rate as compared with the rate of drunk-driver caused fatalities and disability?