4 ms·

There are various antiviral drugs which are orders of magnitude more expensive, have mediocre efficacy and a worse side effect profile compared to any of the ma

There are various antiviral drugs which are orders of magnitude more expensive, have mediocre efficacy and a worse side effect profile compared to any of the main vaccines, and must be started within days of initial infection to work properly. They are a great addition (besides vaccines and non-pharmaceutical public health measures) for treating high-risk patients for whom the vaccines don’t provide perfect protection (e.g. the very elderly and immune compromised), but a poor primary response.

landemva 5y ago
Ivermectin has anti-viral properties, has great multi-decade safety history, and is cheaper than a soda. It also has been shown to be an effective treatment when used early in disease.
- wux 5y ago
  The Cochrane Reviews are regarded as one of the preeminent collections of systematic reviews in medicine. They conclude that “overall, the reliable evidence available does not support the use of ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials.” https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD... A similar conclusion regarding lack of evidence is discussed in NIH treatment guidelines: https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/ https://www.covid19treatmentguidelines.nih.gov/therapies/ant... In line with consensus in the field, ivermectin is not contained among the treatment guidelines of any institution at which I have practiced.
  - TheSpiceIsLife 5y ago
    The Cochrane Collaboration can be safely disregarded by those who’s beliefs do not align with it’s reviews. <overly dramatic eye roll>
- pcwalton 5y ago
  We just had an article about this. I am loath to link to Scott Alexander, but it's the most likely thing to persuade HN users. https://astralcodexten.substack.com/p/ivermectin-much-more-than-you-wanted https://astralcodexten.substack.com/p/ivermectin-much-more-t...
  - smnrchrds 5y ago
    How come? Why do you loath to link to his writings?
  - honkdaddy 5y ago
    Why point out that you loathe someone before linking their work? What an odd, pompous thing to say.
    - jacobolus 5y ago
      loath ≠ loathe loath is an adjective meaning reluctant. loathe is a verb meaning disgust/hate.
      - joenot443 5y ago
        Ugh, silly mistake on my part.
- stjohnswarts 5y ago
  Ivermectin has been shown over and over to be no better than placebo. Sure it has it's uses but covid ain't one of them.

landemva 5y ago

Ivermectin has anti-viral properties, has great multi-decade safety history, and is cheaper than a soda. It also has been shown to be an effective treatment when used early in disease.

wux 5y ago
The Cochrane Reviews are regarded as one of the preeminent collections of systematic reviews in medicine. They conclude that “overall, the reliable evidence available does not support the use of ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials.” https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD... A similar conclusion regarding lack of evidence is discussed in NIH treatment guidelines: https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/ https://www.covid19treatmentguidelines.nih.gov/therapies/ant... In line with consensus in the field, ivermectin is not contained among the treatment guidelines of any institution at which I have practiced.
- TheSpiceIsLife 5y ago
  The Cochrane Collaboration can be safely disregarded by those who’s beliefs do not align with it’s reviews. <overly dramatic eye roll>
pcwalton 5y ago
We just had an article about this. I am loath to link to Scott Alexander, but it's the most likely thing to persuade HN users. https://astralcodexten.substack.com/p/ivermectin-much-more-than-you-wanted https://astralcodexten.substack.com/p/ivermectin-much-more-t...
- smnrchrds 5y ago
  How come? Why do you loath to link to his writings?
- honkdaddy 5y ago
  Why point out that you loathe someone before linking their work? What an odd, pompous thing to say.
  - jacobolus 5y ago
    loath ≠ loathe loath is an adjective meaning reluctant. loathe is a verb meaning disgust/hate.
    - joenot443 5y ago
      Ugh, silly mistake on my part.
stjohnswarts 5y ago
Ivermectin has been shown over and over to be no better than placebo. Sure it has it's uses but covid ain't one of them.