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By no means am I an expert, but my understanding is that vaccines don’t go far enough. They provide B-Cell immunity, which doesn’t last permanently because newe
by mise_en_place 5y ago
By no means am I an expert, but my understanding is that vaccines don’t go far enough. They provide B-Cell immunity, which doesn’t last permanently because newer variants have different antigens. Getting COVID after vaccination seems to be the most robust, because there is both T-Cell and B-Cell activation.
- alevskaya 5y agoI used to work in immunology - this is not accurate. We know that e.g. mRNA vaccines elicit quite a good T-cell immune response. e.g. for one of many studies looking at T-cell responses to the recent sars-cov-2 vaccines: https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3
- sjwalter 5y agoWhy does vaccine-based immunity lack the durability of natural immunity?
- rmk 5y agoIs this true?
- disambiguation 5y agoDurability is an abstract quality, it could mean long lasting, or effective against variants, or some other resistance qualities.. IMO the science on natural immunity has been lacking, so it's hard to say with certainty. one important thing we do know is that mRNA vaccines only generate an s-protein (the spike) whereas the full virus also includes an n-protein (the nucleocapsid). So vaccine immunity one trains against one protein whereas natural infections may train against both. This could be the basis for comprehensive immunity.. but I'll reiterate, it depends on scientific confirmation.