Reminds me how the old-world diseases wreaked havoc in the Americas in the 16-19th centuries: It is estimated that current-day Mexico's population had plummeted

Reminds me how the old-world diseases wreaked havoc in the Americas in the 16-19th centuries: It is estimated that current-day Mexico's population had plummeted from 25 million to 1 million between 1500 and 1550. Even the bubonic plague in Europe in the 1350s did not have such a devastating effect.