From what I understand, there's no way to predict the pros and cons of the original antigenic sin. You will be biased against the strain you first receive, eith

From what I understand, there's no way to predict the pros and cons of the original antigenic sin. You will be biased against the strain you first receive, either as a vaccine or by catching the virus itself. What we don't know is which of these strains 20 years from now will make a resurgence. When that happens, you will be lucky if it's the strain closest to the first strain you caught or received a vaccine for, and unlucky if it isn't. Finally, I understand that vaccines for specific strains still work, but they won't work as well for mutations of their strains and might not get you immunity for as long.