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Is original antigenic sin due to prior vaccination or natural infection a concern for developing a new vaccine for this variant? Or perhaps the B.1.1.529 spike
by sterlind 5y ago
Is original antigenic sin due to prior vaccination or natural infection a concern for developing a new vaccine for this variant? Or perhaps the B.1.1.529 spike is so different that the original antibodies won't bind to it, even ineffectively? Or is there a way to design the new vaccine explicitly so that antibodies produced by prior strains can't bind the new antigens?
- didibus 5y agoFrom what I understand, there's no way to predict the pros and cons of the original antigenic sin. You will be biased against the strain you first receive, either as a vaccine or by catching the virus itself. What we don't know is which of these strains 20 years from now will make a resurgence. When that happens, you will be lucky if it's the strain closest to the first strain you caught or received a vaccine for, and unlucky if it isn't. Finally, I understand that vaccines for specific strains still work, but they won't work as well for mutations of their strains and might not get you immunity for as long.