> Natural immunity targets the whole virus, so whatever immune-escape such a virus evolves, it would have to be far more comprehensive to have a significant eff

> Natural immunity targets the whole virus, so whatever immune-escape such a virus evolves, it would have to be far more comprehensive to have a significant effect. I never thought about it that way. That would mean, if the virus evolves a more efficient ACE-2 binding domain that the mRNA vaccines fail to recognize, the vaccinated population would be more at risk than the unvaccinated population who has been previously exposed.