5 ms·

You didn't mention any negative effects of approaching vitamin D overdose, did you experience any or was this simply a concern of your doctor?

by toolz 5y ago

PragmaticPulp 5y ago
Some of the worst effects aren't immediately obvious, such as metastatic calcification of tissues over time. Long-term effects aren't fully elucidated because high Vitamin D doses weren't common until recently. However, there is growing evidence that excess Vitamin D can contribute to worsening cardiovascular disease and premature aging of cells. You won't necessarily feel the effects of too-high Vitamin D levels right away, but years or decades of excess Vitamin D could do a lot of hidden damage without any benefit over moderate levels.
- vixen99 5y ago
  > there is growing evidence Since you don't say what 'excessive' is, we don't know whether your comment is significant or not. Can you please avoid making statements like this without adding a link to a peer-reviewed paper so that we can assess it. EU study from 2012: https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2012.2813 https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.... As to excessive dose: " Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification, especially if another important finding is included. Even when calcium blood levels are high, the culprit for undesirable vascular calcification is not vitamin D but insufficient blood levels of vitamin K2". COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis: Front Public Health. 2021; 9: 624559. Just found this (staring me in the face, a pdf link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973108/pdf/fpubh-09-624559.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973108/pdf/fpu...
  - sowbug 5y ago
    A suggestion: your otherwise helpful reply might be more effective without upbraiding the commenter you're replying to. (Yes, irony noted that I'm upbraiding you.)
  - spfzero 5y ago
    Also, you can buy supplements that combine D3 with K2, if you are concerned about calcium transport.

You didn't mention any negative effects of approaching vitamin D overdose, did you experience any or was this simply a concern of your doctor?

by toolz 5y ago

You didn't mention any negative effects of approaching vitamin D overdose, did you experience any or was this simply a concern of your doctor?

PragmaticPulp 5y ago

Some of the worst effects aren't immediately obvious, such as metastatic calcification of tissues over time. Long-term effects aren't fully elucidated because high Vitamin D doses weren't common until recently. However, there is growing evidence that excess Vitamin D can contribute to worsening cardiovascular disease and premature aging of cells. You won't necessarily feel the effects of too-high Vitamin D levels right away, but years or decades of excess Vitamin D could do a lot of hidden damage without any benefit over moderate levels.

vixen99 5y ago
> there is growing evidence Since you don't say what 'excessive' is, we don't know whether your comment is significant or not. Can you please avoid making statements like this without adding a link to a peer-reviewed paper so that we can assess it. EU study from 2012: https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2012.2813 https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.... As to excessive dose: " Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification, especially if another important finding is included. Even when calcium blood levels are high, the culprit for undesirable vascular calcification is not vitamin D but insufficient blood levels of vitamin K2". COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis: Front Public Health. 2021; 9: 624559. Just found this (staring me in the face, a pdf link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973108/pdf/fpubh-09-624559.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973108/pdf/fpu...
- sowbug 5y ago
  A suggestion: your otherwise helpful reply might be more effective without upbraiding the commenter you're replying to. (Yes, irony noted that I'm upbraiding you.)
- spfzero 5y ago
  Also, you can buy supplements that combine D3 with K2, if you are concerned about calcium transport.