3 ms·

People react irrationally to this. It is like when people have been evacuated away from earth quake and now it is necessary to evacuate them away from tsunami,

People react irrationally to this. It is like when people have been evacuated away from earth quake and now it is necessary to evacuate them away from tsunami, suddenly they start becoming to question government actions. Delta has 1000x viral load compared to the Wuhan variant. Don't be stupid, take the 3rd jab, 2 jabs is not going to be enough against it.

spurgu 5y ago
What? I have no clue where you're getting the "1000x viral load" from? And in any case if you're young and healthy there's nothing to fear from Covid. The only argument to be made is that the vaccine slightly decreases transmission rate. If you're old or in a risk group by all means have all the jabs and boosters you want, but it doesn't make a lot of sense for the young and healthy and should definitely be left to personal choice.
- nojokes 5y ago
  There you go https://www.google.com/search?q=delta+1000+times+viral+load https://www.google.com/search?q=delta+1000+times+viral+load If you call about 60-70% less transmission a little then you are right. Booster will increase this a little about 5x. Now get your booster and get of those anti-vaxxer sites you have been on lately.
  - spurgu 5y ago
    How about you for example read the first link there and stop spreading hyperbole: https://www.medpagetoday.com/special-reports/exclusives/93717 https://www.medpagetoday.com/special-reports/exclusives/9371...
    - nojokes 5y ago
      So you found your evidence for 1000x more viral load? It does not mean that it is 1000x more infectious and I did not say that. It "only" 50-100% more but this 1000x higher viral load also means that contacting it will bring you in contact with higher viral load and you need higher concentration of neutralizing antibodies to clear the virus to avoid infection. There are simple means to increase those antibody levels - booster shots.
      - perl4ever 5y ago
        If the virus has mutated so much, shouldn't there be new vaccines? I'm kind of doubtful about the idea that delta, being different, means we need another dose of the vaccines that were developed for the original virus. In a few months, there may be something that is on beyond delta circulating. With flu, we expect the vaccines to be updated. The other issue I have is that my first shot (Pfizer) didn't bother me at all, but the second caused a lot of pain in my arm and a fairly short, but miserable overall feeling of illness. This contrasts with my experience of the flu shot, where the very first time, I felt almost as bad as the actual flu, for 1/5th of the time, but on subsequent years, had no reaction at all. What I'm saying is, two data points make a trend, even if not a terribly reliable one, and I don't have a good argument for why a third shot would not be as bad or worse. I think I've read that the reaction may be largely to inactive ingredients and not the vaccine itself. What does that mean? I don't know, but I can worry that the more times I'm exposed, the worse it will be. I've also read that the Moderna vaccine provided better immunity in retrospect, and you can probably choose whatever you want for your third. It seems like at the moment, cases are up, but fatalities are down. If I get the sense that half of the population has had a booster, or that vaccinated people are being hospitalized, maybe I will. Otherwise, I'm not in a rush.
        nojokes 5y ago
        Delta has improved in cell machinery and better cleavage site (point where its spike protein splits in half when entering the cell) but outside of it is well recognizable for current vaccine induced antibodies. There is no need for a new vaccine against it, just more antibodies to clear normally higher viral load that comes with it, so more of the same vaccine is better than something completely new. For data points, data from Israel states that third shot has been more tolerable than the second one in general with less frequent and less serious side effects. I will get mine in coming week and I can tell you about my personal experience - two previous shots gave me just pain in the injection site. Pfizer and Moderna chose a little different optimization strategy - Moderna went with higher mRNA dose (3x higher than Pfizer), Pfizer tested also smaller dose, saw that it produces about the same result but with less side effects and went with lower concentration. Now it appears that immunity from Moderna shot is longer lasting but it really does have more side effects than Pfizer. I think it is also the reason why the booster dosage of Moderna vaccine is half of its initial dosage. So perhaps it still will provide a little better immunity having about 1.5 mRNA concentration of Pfizer and has now about the same level of side effects. Hard to say at the moment.

spurgu 5y ago

What? I have no clue where you're getting the "1000x viral load" from? And in any case if you're young and healthy there's nothing to fear from Covid. The only argument to be made is that the vaccine slightly decreases transmission rate. If you're old or in a risk group by all means have all the jabs and boosters you want, but it doesn't make a lot of sense for the young and healthy and should definitely be left to personal choice.

nojokes 5y ago
There you go https://www.google.com/search?q=delta+1000+times+viral+load https://www.google.com/search?q=delta+1000+times+viral+load If you call about 60-70% less transmission a little then you are right. Booster will increase this a little about 5x. Now get your booster and get of those anti-vaxxer sites you have been on lately.
- spurgu 5y ago
  How about you for example read the first link there and stop spreading hyperbole: https://www.medpagetoday.com/special-reports/exclusives/93717 https://www.medpagetoday.com/special-reports/exclusives/9371...
  - nojokes 5y ago
    So you found your evidence for 1000x more viral load? It does not mean that it is 1000x more infectious and I did not say that. It "only" 50-100% more but this 1000x higher viral load also means that contacting it will bring you in contact with higher viral load and you need higher concentration of neutralizing antibodies to clear the virus to avoid infection. There are simple means to increase those antibody levels - booster shots.
    - perl4ever 5y ago
      If the virus has mutated so much, shouldn't there be new vaccines? I'm kind of doubtful about the idea that delta, being different, means we need another dose of the vaccines that were developed for the original virus. In a few months, there may be something that is on beyond delta circulating. With flu, we expect the vaccines to be updated. The other issue I have is that my first shot (Pfizer) didn't bother me at all, but the second caused a lot of pain in my arm and a fairly short, but miserable overall feeling of illness. This contrasts with my experience of the flu shot, where the very first time, I felt almost as bad as the actual flu, for 1/5th of the time, but on subsequent years, had no reaction at all. What I'm saying is, two data points make a trend, even if not a terribly reliable one, and I don't have a good argument for why a third shot would not be as bad or worse. I think I've read that the reaction may be largely to inactive ingredients and not the vaccine itself. What does that mean? I don't know, but I can worry that the more times I'm exposed, the worse it will be. I've also read that the Moderna vaccine provided better immunity in retrospect, and you can probably choose whatever you want for your third. It seems like at the moment, cases are up, but fatalities are down. If I get the sense that half of the population has had a booster, or that vaccinated people are being hospitalized, maybe I will. Otherwise, I'm not in a rush.
      - nojokes 5y ago
        Delta has improved in cell machinery and better cleavage site (point where its spike protein splits in half when entering the cell) but outside of it is well recognizable for current vaccine induced antibodies. There is no need for a new vaccine against it, just more antibodies to clear normally higher viral load that comes with it, so more of the same vaccine is better than something completely new. For data points, data from Israel states that third shot has been more tolerable than the second one in general with less frequent and less serious side effects. I will get mine in coming week and I can tell you about my personal experience - two previous shots gave me just pain in the injection site. Pfizer and Moderna chose a little different optimization strategy - Moderna went with higher mRNA dose (3x higher than Pfizer), Pfizer tested also smaller dose, saw that it produces about the same result but with less side effects and went with lower concentration. Now it appears that immunity from Moderna shot is longer lasting but it really does have more side effects than Pfizer. I think it is also the reason why the booster dosage of Moderna vaccine is half of its initial dosage. So perhaps it still will provide a little better immunity having about 1.5 mRNA concentration of Pfizer and has now about the same level of side effects. Hard to say at the moment.