If you can, definitely standardize on as few distros as possible. It'll make applying patches (and learning when things go wrong, because they will) much easier

If you can, definitely standardize on as few distros as possible. It'll make applying patches (and learning when things go wrong, because they will) much easier. We used to have all sorts of distros that people just felt like using without worrying about their maintainability. We kept fighting fires to keep everything running. Once we standardized on a single distro (CentOS at the time), everything started working much more smoothly. We could have picked Debian, Ubuntu, it doesn't matter. That being said, Amazon Linux 2 is pretty well maintained. Most things (all?) that work on RHEL, will work on it. You may need to use 3rd-party repos if you want really newer stuff (eg. PHP) but that's inherent to such LTS releases. That situation is expected to improve with the improvements that adopting Fedora brings in AL2022 but I need to catch up.